Our group develops innovative RNA and gene-based therapeutic strategies for neuromuscular disorders, with a strong focus on translational research bridging mechanistic insights and preclinical development.

Research Project

The successful candidate will contribute to research programs aimed at enhancing the efficacy of antisense oligonucleotide (ASO) and related RNA-based therapies. These projects integrate molecular, cellular, and in vivo approaches to address key challenges in therapeutic delivery, intracellular activity, and tissue targeting.

This work will involve investigating the molecular determinants of therapeutic efficiency and developing strategies to improve the performance of RNA-based interventions in relevant disease models.

Candidate Profile

We seek a highly motivated and creative scientist holding a PhD in molecular biology, genetics, neuroscience, or a related discipline.

The ideal candidate will have:

• Strong expertise in RNA and molecular biology (e.g. qPCR, Western blot, imaging, cloning, cell culture)
• Prior experience in antisense oligonucleotides, siRNA, or RNA therapeutics
• Experience with in muscle biology and in vivo models (mouse) is highly desirable
• Interest in neuromuscular biology or muscle therapeutics
• Ability to drive independent projects, critically analyze data, and develop novel research directions

Research Environment

The IMPROVE unit provides a highly collaborative and interdisciplinary environment, with access to state-of-the-art facilities and strong interactions with engineers, PhD students, and academic collaborators.

Employment Conditions

• Start date: June 2026 (flexible)
• Duration: up to 3 years
• Salary: according to INSERM/University scales, based on experience

Application

Applicants should submit:

• A cover letter describing research interests and experience
• A detailed CV
• Contact information for 2–3 referees

to: aurelie.goyenvalle@uvsq.fr