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X-WR-CALNAME:Oligonucleotide Therapeutics Society
X-WR-CALDESC:Oligonucleotide Therapeutics Society
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DTSTART:20260514T204732
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UID:MEC-dbc6c17187c477fd469d54482dd7001a@oligotherapeutics.org
DTSTART;TZID=UTC:20240425T170000
DTEND;TZID=UTC:20240425T180000
DTSTAMP:20240412T035903Z
CREATED:20240412
LAST-MODIFIED:20240412
PRIORITY:5
SEQUENCE:0
TRANSP:OPAQUE
SUMMARY:In vivo Optical Control of Gene-Silencing in Japanese Medaka Fish Embryos
DESCRIPTION:The siRNA oligonucleotide duplex inherent to biology, functions by binding and cleaving mRNA, a process known as the RNA interference (RNAi) pathway. Our lab has taken an interest in designing tetrafluorinated azobenzene, which has the unique ability to switch conformation from a trans to cis state when exposed to light. The ortho-functionalized, tetrafluorinated azobenzene was integrated into siRNAs via phophoramidite chemistry to generate a class of photoswitchable tetrafluorinated azobenzene-functionalized siRNAs (F-siRNAs). These F-siRNAs retained the ability to photoisomerize from an active trans to an inactive cis state through blue and green light, respectively, in Japanese Medaka embryos.\n
URL:http://oligotherapeutics.org/in-vivo-optical-control-of-gene-silencing-in-japanese-medaka-fish-embryos/
CATEGORIES:Webinar
ATTACH;FMTTYPE=image/webp:https://oligotherapeutics.org/wp-content/uploads/2024/04/4-25-20241.webp
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