Location: Remote
Company: OS Therapeutics Inc., a Delaware corporation (“OS Tx”)

Application Process

To apply, please submit your resume and a brief cover letter outlining your qualifications and interest in the role to hiring@ostherapeutics.com.

About OS Tx

OS Therapeutics is a fast-growing US biotech company build around a mission to make the impossible possible for patients facing difficult-to-treat diseases. We are pioneering next-generation therapeutics that turn breakthrough science into life-changing therapies. That vision is built on a validated scientific platform, a focused strategy with a clear development roadmap, and a team with a track record of disciplined execution. Together, they position us toward a bold ambition: bringing transformative medicines to the patients and improving lives with speed and scientific discipline.

Position Overview

OS Therapeutics is seeking a Chemistry Consultant (part-time) with industry experience in siRNA therapeutics to support our discovery and preclinical development efforts, working closely with the leadership team. Operating in a lean, fast-paced startup environment, the consultant will provide expert guidance on oligonucleotide design and optimization, review chemistry data, and advise on candidate development. This is a high-impact advisory engagement for an experienced oligonucleotide chemist who enjoys translating chemistry insights into differentiated drug candidates.

Key Responsibilities

• Advise on siRNA design and optimization, including sequence selection, chemical modifications, and conjugation strategies.
• Review and interpret chemistry and analytical data and provide recommendations to the program and leadership teams.
• Advise on candidate selection and development, including developability and readiness for preclinical studies.
• Guide work with external partners (CROs/CDMOs) on oligonucleotide synthesis, scale-up, and early CMC as needed.

Qualifications

• PhD in Chemistry (organic, medicinal, or nucleic acid chemistry preferred)
• Demonstrated industry track record in oligonucleotide therapeutics, including advancing programs to candidate nomination or IND.
• Deep expertise in oligonucleotide chemistry, including chemical modifications, conjugation, and
• Familiarity with oligonucleotide CMC, analytical characterization, and regulatory considerations.

Desired Attributes

• Hands-on, pragmatic, and resourceful—comfortable rolling up sleeves and executing.
• Strong interpersonal skills and the ability to build trust across scientific, operational, and partner ecosystems.
• High personal integrity and ability to handle confidential information with discretion.

Why Join OS Tx?

• Opportunity to shape and build a pioneering biotech company at a formative stage.
• Collaborative and innovative culture with direct exposure to scientific and corporate decision-making.
• Meaningful career growth opportunities as the company scales toward clinical development.

OS Tx is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

The Interventional Genetics Scholar Program puts early-career scientists and clinicians into leadership roles inside the N=1 Collaborative: the global network working to make individualized therapies scalable. Join our team across our six leadership roles.

SCHOLARS GAIN:

• Hands-on leadership experience running a live N1C program
• Direct mentorship from leaders in the field
• Visibility across the interventional-genetics community
• Lifetime membership in a global network of N1C alumni
• Funded travel + registration to N1C Annual Meeting

ELIGIBILITY:

• Current undergraduate/graduate student, postdoc, or clinical trainee
• Experience with or interest in individualized medicine
• Highly motivated trainee with strong organizational and interpersonal skills
• Ability to volunteer ~5 hours/week over a two year term
• Supervisor approval

This is a volunteer-based position. Please learn more on our website. We hope to connect with you soon!

• Effective organizational and time management skills, with the ability to perform under minimal
supervision.
• Capable of overcoming a steep learning curve within a fast-paced startup environment.
• Experience working in a start-up or small company environment is a plus.
What we offer you
• Competitive Compensation
• Medical, Dental and Vision Insurance
• 401k with Company Match
• Paid Time Off (PTO)
• Flexible work schedule
• The opportunity to help build a department, influence policy and be a part of a team doing
impactful work!
What to expect
• Location – This is a remote position, supporting customers that reside on the West Coast and in
some instances, internationally. The ability to adjust to customer time zones is essential.
• Travel – Up to 30% travel is required. Travel may consist of customer visits and conference
attendance. Reasonable travel expenses will be covered by the company, in accordance with the
Synoligo Travel Policy.
Synoligo Biotechnologies is proud to be an equal opportunity workplace and employer. Synoligo’s policies
and practices relating to recruitment, employment, career development/advancement, promotion, and
retirement are based solely on merit, regardless of race, color, religion, ancestry, sex (including
pregnancy, lactation, sexual orientation, gender identity, or gender expression), national origin, age,
citizenship, marital status, mental or physical disability, genetic information (including family medical
history), discharge status from the military, protected veteran status (which includes disabled veterans,
recently separated veterans, active duty wartime or campaign badge veterans, and Armed Forces service
medal veterans), or any other basis protected by law. If you have a disability or special need that requires
accommodation, please let us know during the recruitment process.

As a Bioanalytical Scientist, you will be working alongside a small team of highly motivated scientists. Responsible for oligonucleotide bioanalytical assay development, you will help influence the advancements of science, your career, and a growing biotechnology start-up.

What you’ll do in this role:

• Build internal oligo bioanalytical capabilities and lead external client projects focused on PK, PD, biomarker or immunogenicity of siRNA/ASO therapeutics.
• Design and execute oligo bioanalytical assays, including SL-qPCR/ddPCR, hybridization ELISA, RISC loading assay and protein-based assays (ELISA, JESS, MSD, IHC).
• Establish in-house workflow to process animal tissues and extract DNA, RNA, and protein for downstream assays.
• Leverage depth of knowledge to analyze and interpret assay data; prepare reports and communicate results to clients on a regular basis.
• Support internal instrument validation, assay optimization, and SOP development.
• Participate in client-based project meetings as subject matter expert and support new project onboarding, planning and progress discussions

What you bring to the table:

• Ph.D. in Cell Biology, Molecular Biology, Pharmaceutical Sciences, Biochemistry, or a related field.
• 0–3 years (Scientist), 3-5 years (Sr. Scientist) of relevant industry experience in a CRO, biotechnology, or pharmaceutical setting, with demonstrated achievements.
• Hands-on experience with qPCR, ddPCR, JESS, ELISA, MSD and other immunoassays.
• Proven experience with animal tissues processing and homogenization, nucleic acid/protein extraction and immunoprecipitation.
• Experience with cell-based assay is highly desirable.
• Knowledge of primer-probe design, oligo thermodynamic properties and chemical modifications is preferred.
• Experience with LC-MS for oligo quantification (e.g., siRNA, ASO) is a plus.
• Strong communication, organizational, and problem-solving skills, with the ability to work both independently and collaboratively.

What we offer you

• Competitive Compensation
• Medical, Dental, Vision and Life Insurance
• 401k with Company Match
• Paid Time Off (PTO)
• Flexible work schedule
• The opportunity to help build a department, influence policy and be a part of a team doing impactful work!

Job Type: Full-time

Work Location: In person

Synoligo Biotechnologies is proud to be an equal opportunity workplace and employer. Synoligo’s policies and practices relating to recruitment, employment, career development/advancement, promotion, and retirement are based solely on merit, regardless of race, color, religion, ancestry, sex (including pregnancy, lactation, sexual orientation, gender identity, or gender expression), national origin, age, citizenship, marital status, mental or physical disability, genetic information (including family medical history), discharge status from the military, protected veteran status (which includes disabled veterans, recently separated veterans, active duty wartime or campaign badge veterans, and Armed Forces service medal veterans), or any other basis protected by law. If you have a disability or special need that requires accommodation, please let us know during the recruitment process.