The French Day of Therapeutic Oligonucleotides brings together researchers from academia and industry, clinicians, biotechnology and pharmaceutical companies, technology providers, investors, and patient representatives. The meeting showcases recent advances in antisense oligonucleotides, siRNA, RNA editing, RNA-targeted therapeutics, delivery technologies, oligonucleotide chemistry, and clinical translation, while fostering education, scientific exchange, and collaborations across the French therapeutic oligonucleotide community.