Developing Sustainable Methods for the Large-Scale Manufacture of Pharmaceuticals Containing Nucleosides. The conference will emphasize innovations that enhance sustainability, scalability, and robustness in synthesis methodologies. We are inviting leading experts to present their work through case studies of large-scale process implementation and emerging synthetic methods with potential for sustainable industrial impact. The Urgent Need!  Recent medical advancements have exposed a major bottleneck.  While demand for nucleoside-containing pharmaceuticals is growing rapidly, current synthetic methods fall short—both in scale and sustainability. We will also host a Panel Discussion to talk about these issues.

• Solid-phase oligonucleotide synthesis is typically capped at <10 kg per batch
• Demand now exceeds multi-ton quantities
• Waste is staggering—over 1,000 kg of waste per 1 kg of product (R. Obexer et al., Science, 2024, 384 (6692), eadl4015. DOI)

ChemTides will bring together leading scientists to share solutions, breakthroughs, and vision for a more scalable and sustainable future in this space. Be part of the 2nd ChemTides Conference and help shape the future of this vital field. Join Us in San Diego – March 23, 2027