Scientist/Senior Scientist, RNA Analytical Development

We are seeking an innovative Scientist/Senior Scientist in RNA Analytical Development to establish and execute analytical strategies across multiple RNA modalities, including mRNA, ASOs, siRNAs, and gRNAs. The successful candidate will develop scalable, phase-appropriate analytical workflows to support platform development, product quality, and translational research programs.

Key Responsibilities

• Develop and implement analytical characterization strategies for RNA raw materials, drug substances, and drug products.
• Establish analytical workflows using techniques such as HPLC, LC-MS, CE, qPCR, DLS, and TEM.
• Apply Quality by Design (QbD) principles to define critical quality attributes (CQAs) and ensure method robustness and scalability.
• Collaborate with cross-functional teams to support product and process development.
• Develop and maintain SOPs, validation plans, and analytical documentation in compliance with regulatory expectations.
• Maintain data integrity and traceability through LIMS/ELN systems.
• Prepare technical reports, presentations, and stakeholder updates.
• Stay current with emerging analytical technologies and regulatory developments in RNA therapeutics.

Qualifications & Experience

• PhD in Analytical Chemistry, Pharmaceutical Sciences, or a related field.
• Minimum 4 years (Scientist) or 8 years (Senior Scientist) of analytical development experience in nucleic acid therapeutics within pharmaceutical or biotechnology organizations.
• Hands-on experience with purification technologies, including HPLC, ion-exchange, affinity, hydrophobic interaction, size-exclusion chromatography, and tangential flow filtration.
• Strong expertise in analytical characterization techniques such as LC-MS, LC-HRMS, CE-SDS, DSC, HIC, and NMR.
• Experience developing LC-MS workflows for characterization and QC of oligonucleotides and conjugated RNA therapeutics.
• Experience establishing automated, high-throughput analytical capabilities is desirable.
• Familiarity with analytical method validation, CMC documentation, and IND-enabling development activities.
• Strong problem-solving, communication, and stakeholder management skills.
• Ability to work independently in a fast-paced, multidisciplinary environment.
• This position is based in Singapore. Successful candidates must be willing to relocate to Singapore.