Antibody-Oligonucleotide Conjugate (AOC), Scientist/Senior Scientist

About the Job

Title: Antibody-Oligonucleotide Conjugate (AOC), Scientist/Senior Scientist

Type: Full-time, On site

Location: Boston MA

NuCyRNA Therapeutics

NuCyRNA Therapeutics was founded by a small team of scientists with a shared mission: to rethink RNA-targeting therapeutics and bring true disease-modifying treatments to patients with devastating neurodegenerative diseases. Backed by Mission BioCapital, we’ve built a platform that unlocks entirely new RNA-targeting capacities—particularly in the CNS—where safety and precision matter the most.

We are now expanding our platform into targeted CNS delivery using Antibody–Oligonucleotide Conjugates (AOCs), a key strategic pillar for the company. NuCyRNA is seeking a Scientist/Senior Scientist with a strong background in Antibody-Oligonucleotide Conjugate (AOC).

Your Role

As one of NuCyRNA’s earliest scientific hires, you won’t just “execute experiments”—you’ll shape the scientific direction of a company from the ground up. You will

1. Lead the preclinical development of AOC candidates in close collaboration with founders, advisors, and CRO partners.
2. Oversee CROs across study design, execution, troubleshooting, and data interpretation for in vitro and in vivo studies.
3. Conduct targeted in-house in vitro experiments as needed.

Your work will directly influence which AOC candidate(s) move toward IND-enabling studies—and ultimately, toward patients.

Skills & background

1. Strong technical background in ADCs; direct experience with AOCs, antibody engineering, or conjugation chemistry is highly preferred.
2. Experience with brain-shuttle technologies is a strong plus.
3. PhD or MD in a relevant field; exceptional candidates with significant experience and without a doctorate will be considered.
4. Prior industry experience is a plus but not mandatory. Fresh PhD graduates and post-docs are welcome to apply.

Compensation

We offer competitive salary and equity packages aligned with experience and the company’s early-stage growth trajectory.

Career Advancement Opportunities

As one of the first full-time scientific hires, you’ll work directly with NuCyRNA Therapeutics’ founders, advisors, and CROs. This position offers exposure to multiple startup aspects, including scientific research, business operations, strategic planning, and intellectual property management. The role provides opportunities for rapid professional growth and financial rewards as the company expands.