Principal Scientist – Discovery Biology

Role Overview

We are seeking a highly motivated and skilled Principal Scientist to join our team. The successful candidate will lead the biological evaluation of ASO from early discovery through lead identification for cardiac therapeutic applications. This role is responsible for developing and executing ASO screening cascades, building disease-relevant in vitro and in vivo models, and driving the biological characterization of candidate molecules.

They will work cross-functionally with chemistry, bioinformatics, and translational teams to advance our early pipeline, helping to define the next generation of RNA-targeted therapies.

Key Responsibilities

• Lead the biological evaluation of ASO candidates to support lead optimization and candidate selection.
• Build and validate disease-relevant cellular and molecular models (e.g., primary cells, iPSC-derived models, organoids, etc.) for ASO screening and mechanistic studies.
• Design, develop, and implement high-throughput in vitro screening assays for ASO activity, selectivity, uptake, and toxicity.
• Design and execute in vivo pharmacology studies to assess ASO distribution, target engagement, efficacy, and safety.
• Work closely with internal med chem and oligo synthesis teams to guide rational ASO design, and lead CRO and academic collaborations and ensuring high-quality data generation.
• Organise, analyse and interpret complex biological datasets to identify key insights that will inform future research activities and business strategy and clearly communicating these to relevant internal stakeholders.
• Gathering and analysing external data, including scientific literature and databases, regulatory filings, clinical trial registries, press releases, industry reports and trends to identify both potential collaborative opportunities as well as to provide program specific recommendations and insights.
• Mentor junior scientists and contribute to building a high-performing research team and culture.
• Maintaining high standards of accuracy, confidentiality, and security when handling sensitive data related to proprietary research findings.
• Help shape the company’s scientific strategy, infrastructure, and R&D roadmap.

Required Qualifications

• PhD in Molecular Biology, Cell Biology, Pharmacology, or a related field, with 7+ years of relevant postdoctoral or industry experience.
• Proven expertise in nucleic acid therapeutics, especially ASOs.
• Strong track record in molecular and cellular biology assay development, including vector design, psiCHECK, QuantiGene assays, qPCR, RT-PCR, ddPCR, Western blotting, ELISA, immunocytochemistry, RNAscope and transcriptome analysis.
• Hands-on experience with cell-based disease models, especially in cardiac diseases and developing transgenic mouse models.
• Strong track record in working with CROs and academic collaborators.
• Excellent experimental design, data analysis, and problem-solving skills.
• Strong written and verbal communication skills; ability to clearly present scientific data and strategies.
• Ability to work in a fast-paced, collaborative startup environment.

Preferred Qualifications

• Experience in early-stage drug discovery or biotech startups.
• Knowledge of RNA biology, splicing regulation, or RNA-protein interactions.
• Experience with high-content imaging, single-cell RNAseq, or transcriptomics.

Why Join Us

• Competitive salary and benefits package.
• Opportunity to be part of an early-stage team shaping the future of a high-impact biotech startup.
• Work at the intersection of cutting-edge science and unmet clinical need.
• Thrive in a fast-paced, collaborative, and supportive startup environment.
• Modern lab and office space in the heart of London’s biotech ecosystem.

How to Apply

Please submit your CV and a brief cover letter outlining your interest and relevant experience to: ashling@cora.bio.com Applications will be reviewed on a rolling basis with the aim to fill the position promptly. Therefore, we encourage qualified individuals to submit their applications without delay.