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Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models
Kim Y, Jo M, Schmidt J, Luo X, Prakash TP, Zhou T, Klein S, Xiao X, Post N, Yin Z, MacLeod AR. Mol Ther. 2019 Jun 29. pii: S1525-0016(19)30304-1. PubMed
July 31, 2019
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
Schleimann MH, Kobberø ML, Vibholm LK, Kjær K, Giron LB, Busman-Sahay K, Chan CN, Nekorchuk M, Schmidt M, Wittig B, Damsgaard TE, Ahlburg P, Hellfritzsch MB, Zuwala K, Rothemejer FH, Olesen R, Schommers P, Klein F, Dweep H, Kossenkov A, …
In Vitro Drug-Drug Interaction Evaluation of GalNAc conjugated siRNAs Against CYP450 Enzymes and Transporters
Ramsden D, Wu JT, Zerler B, Iqbal S, Jiang J, Clausen V, Aluri K, Gu Y, Dennin S, Kim J, Chong S. Drug Metab Dispos. 2019 Jul 3. PubMed
Metabolism and Disposition of Volanesorsen, a 2′ MOE Antisense Oligonucleotide, Across Species
Post N, Yu R, Greenlee S, Gaus H, Hurh E, Matson J, Wang Y. Drug Metab Dispos. 2019 Jul 26. PubMed
Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure-Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin-Mediated (hATTR) Amyloidosis
Zhang X, Goel V, Attarwala H, Sweetser MT, Clausen VA, Robbie GJ. J Clin Pharmacol. 2019 Jul 19. PubMed
Page 86 of 212
Page 86 of 212
Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models
Kim Y, Jo M, Schmidt J, Luo X, Prakash TP, Zhou T, Klein S, Xiao X, Post N, Yin Z, MacLeod AR. Mol Ther. 2019 Jun 29. pii: S1525-0016(19)30304-1. PubMed
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
Schleimann MH, Kobberø ML, Vibholm LK, Kjær K, Giron LB, Busman-Sahay K, Chan CN, Nekorchuk M, Schmidt M, Wittig B, Damsgaard TE, Ahlburg P, Hellfritzsch MB, Zuwala K, Rothemejer FH, Olesen R, Schommers P, Klein F, Dweep H, Kossenkov A, …
In Vitro Drug-Drug Interaction Evaluation of GalNAc conjugated siRNAs Against CYP450 Enzymes and Transporters
Ramsden D, Wu JT, Zerler B, Iqbal S, Jiang J, Clausen V, Aluri K, Gu Y, Dennin S, Kim J, Chong S. Drug Metab Dispos. 2019 Jul 3. PubMed
Metabolism and Disposition of Volanesorsen, a 2′ MOE Antisense Oligonucleotide, Across Species
Post N, Yu R, Greenlee S, Gaus H, Hurh E, Matson J, Wang Y. Drug Metab Dispos. 2019 Jul 26. PubMed
Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure-Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin-Mediated (hATTR) Amyloidosis
Zhang X, Goel V, Attarwala H, Sweetser MT, Clausen VA, Robbie GJ. J Clin Pharmacol. 2019 Jul 19. PubMed
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