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Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. Nat Commun. 2019 May 9;10(1):2127. PubMed
May 31, 2019
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Nat Biotechnol. 2019 May 20. PubMed
Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaks
Rees HA, Yeh WH, Liu DR. Nat Commun. 2019 May 17;10(1):2212. PubMed
Modification of oligonucleotides with weak basic residues via the 2′-O-carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity
Masaki Y, Yamamoto K, Yoshida K, Maruyama A, Tomori T, Iriyama Y, Nakajima H, Kanaki T, Seio K. Org Biomol Chem. 2019 May 15;17(19):4835-4842. PubMed
Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of Small Interfering RNA Duplexes
Malek-Adamian E, Fakhoury J, Arnold AE, MartÃnez-Montero S, Shoichet MS, Damha MJ. Nucleic Acid Ther. 2019 May 14. PubMed
Page 96 of 212
Page 96 of 212
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. Nat Commun. 2019 May 9;10(1):2127. PubMed
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Nat Biotechnol. 2019 May 20. PubMed
Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaks
Rees HA, Yeh WH, Liu DR. Nat Commun. 2019 May 17;10(1):2212. PubMed
Modification of oligonucleotides with weak basic residues via the 2′-O-carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity
Masaki Y, Yamamoto K, Yoshida K, Maruyama A, Tomori T, Iriyama Y, Nakajima H, Kanaki T, Seio K. Org Biomol Chem. 2019 May 15;17(19):4835-4842. PubMed
Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of Small Interfering RNA Duplexes
Malek-Adamian E, Fakhoury J, Arnold AE, MartÃnez-Montero S, Shoichet MS, Damha MJ. Nucleic Acid Ther. 2019 May 14. PubMed
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