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ADAPT identifies an ESCRT complex composition that discriminates VCaP from LNCaP prostate cancer cell exosomes.

Hornung T, O’Neill HA, Logie SC, Fowler KM, Duncan JE, Rosenow M, Bondre AS, Tinder T, Maher V, Zarkovic J, Zhong Z, Richards MN, Wei X, Miglarese MR, Mayer G, Famulok M, Spetzler D. Nucleic Acids Res. 2020 Jan 28. …

• Aptamer
• Hot Papers

January 31, 2020

MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs.

• Anti-miR/antagomir
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• MicroRNA
• mRNA

The effector mechanism of siRNA spherical nucleic acids.

• Ago/siRNA/saRNA
• Delivery
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Scn8a antisense oligonucleotide is protective in mouse models of SCN8A Encephalopathy and Dravet Syndrome.

• Antisense/RNase H
• Hot Papers

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.

• Antisense/RNase H
• Hot Papers