Date: May 21, 2026
Time: 11-12pm EDT / 5-6pm CEST
Title: Bioanalysis of Oligonucleotide Therapeutics via Nucleic Acid Nanorobotic Platform
Description:
Dynamic DNA nanotechnology enables the isothermal and enzyme-free exchange of nucleic acid strands. The underlying mechanism of action in this field is known as toehold-mediated strand displacement. Recently, dynamic DNA nanotechnology has been applied in bioanalysis of oligonucleotide therapeutics. In this webinar the principles behind nucleic acid nanorobotics will be described. Followed by two recently published case studies demonstrating (1) accuracy and precision in ASO quantification direct to mouse plasma and (2) quantification of ASO-small molecules conjugates in plasma and liver tissue pharmacokinetic studies.
