Trainee Spotlight Series: Poster Winners #OTS24 Session 1
Date: January 23, 2025 Time: 11-12pm EST Title: Antisense oligonucleotides targeting linked-SNPs provide allele-specific knockdown of a dominant-negative SPTAN1 pathogenic variant Description: Our first webinar of the year features trainees Christiana Wang, Elaine Kang, and Sinan Faiad, all of whom won poster ...
Mastering the Art of Reviewing Scientific Papers
Date: December 12, 2024 Time: 8am PST / 11am EST / 5pm CET Title: Mastering the Art of Reviewing Scientific Papers Description: Join our webinar on mastering the art of reviewing scientific papers, presented by Prof. Dr. Annemieke Aartsma-Rus, co-editor in ...
mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo
Date: September 19, 2024 Time: 8am PDT / 11am EDT / 5pm CEST Title: mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo Description: Huntington’s disease (HD) is an autosomal dominant neurodegenerative ...
Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2’-O-Methyl Modified Single-Stranded Oligonucleotides
Date: August 29, 2024 Time: 6am PDT / 9am EDT / 3pm CEST Title: Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2’-O-Methyl Modified Single-Stranded Oligonucleotides Description: Single-stranded oligonucleotides (SSOs) are a rapidly expanding class of therapeutics. Chemical modifications such as the ...
Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation
Date: July 25, 2024 Time: 8am PDT / 11am EDT / 5pm CEST Title: Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation Description: Nucleic acid-based therapies have become the third major drug class after small molecules and antibodies. The role of ...
A Nucleic Acid Approach to Antibody Therapeutics
Date: July 18, 2024 Time: 8am PDT / 11am EDT / 5pm CEST Title: A Nucleic Acid Approach to Antibody Therapeutics Description: Monoclonal antibodies represent a highly successful class of therapeutics that are used to treat complex diseases across a wide ...
Application of hydrophobically conjugated siRNAs for the treatment of dermatological and muscular diseases
Date: July 11, 2024 Time: 8am PDT / 11am EDT / 5pm CEST Title: Application of hydrophobically conjugated siRNAs for the treatment of dermatological and muscular diseases Description: This webinar will focus on siRNA delivery to skin and muscle using hydrophobic ...
2023 OTS Paper of the Year Spotlight: A Framework for Individualized Splice-Switching Oligonucleotide Therapy
Date: August 22, 2024 Time: 8am PDT / 11am EDT / 5pm CEST Title: 2023 OTS Paper of the Year Spotlight: A Framework for Individualized Splice-Switching Oligonucleotide Therapy Description: Splice-switching antisense oligonucleotides (ASOs) could be used to treat a subset of ...
Annual Meeting Poster Awardee Spotlight
Date: June 27, 2024 Time: 8am PDT / 11am EDT / 5pm CEST Title: Functional Aptamer Selection for the Low-Complexity Domain of TDP-43 as a Potential Treatment Avenue for ALS Description: Targeting of TAR-DNA Binding Protein-43 (TDP-43), a protein implicated in ...
Branching into RNAi
Date: June 13, 2024 Time: 8am PDT / 11am EDT / 5pm CEST Title: Branching into RNAi Description: Our research focuses on the synthetic short-interfering RNAs (siRNAs) that silences the oncogenic mRNA expression of the Glucose Regulated Proteins (GRPs) leading to ...
