Archive

Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.

Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, Tardif JC, Baum SJ, Steinhagen-Thiessen E, Shapiro MD, Stroes ES, Moriarty PM, Nordestgaard BG, Xia S, Guerriero J, Viney NJ, O’Dea L, Witztum JL; AKCEA-APO(a)-LRx Study Investigators. N Engl J Med. 2020 Jan 1. …

• Antisense/RNase H
• Clinical Development
• Hot Papers

January 31, 2020

Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis.

Sutherland JE, Hettinger JL, Chan A, Gilbert J, Warner GL, Davis WP. Nucleic Acid Ther. 2019 Dec 10. PubMed

• Ago/siRNA/saRNA
• Hot Papers
• Pre-Clinical Research
• Toxicology

Antibody Opsonization of a TLR9 Agonist-Containing Virus-like Particle Enhances In Situ Immunization.

Lemke-Miltner CD, Blackwell SE, Yin C, Krug AE, Morris AJ, Krieg AM, Weiner GJ. J Immunol. 2020 Jan 17. pii: ji1900742. PubMed

• Hot Papers
• Immune Stimulation

Sequence Multiplicity within Spherical Nucleic Acids.

Huang ZN, Cole LE, Callmann CE, Wang S, Mirkin CA. ACS Nano. 2020 Jan 28;14(1):1084-1092. PubMed

• Delivery
• Hot Papers
• Immune Stimulation

Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Installed Polymeric Nanocarrier.

Min HS, Kim HJ, Naito M, Ogura S, Toh K, Hayashi K, Kim BS, Fukushima S, Anraku Y, Miyata K, Kataoka K. Angew Chem Int Ed Engl. 2020 Jan 29. PubMed

• Antisense/RNase H
• Delivery
• Hot Papers
• Long noncoding RNA