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Phosphorothioate Antisense Oligonucleotides Bind P-Body Proteins and Mediate P-Body Assembly

• Antisense/RNase H

August 31, 2019

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

• Ago/siRNA/saRNA

Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway

• Alternative splicing
• Long noncoding RNA

miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease

• Anti-miR/antagomir
• MicroRNA

Therapeutic inhibition of microRNA-34a ameliorates aortic valve calcification via modulation of Notch1-Runx2 signaling

Toshima T, Watanabe T, Narumi T, Otaki Y, Shishido T, Aono T, Goto J, Watanabe K, Sugai T, Takahashi T, Yokoyama M, Kinoshita D, Tamura H, Kato S, Nishiyama S, Arimoto T, Takahashi H, Miyamoto T, Sadahiro M, Watanabe M. …

• Anti-miR/antagomir
• MicroRNA