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Enhancing gene editing specificity by attenuating DNA cleavage kinetics

Miller JC, Patil DP, Xia DF, Paine CB, Fauser F, Richards HW, Shivak DA, Bendaña YR, Hinkley SJ, Scarlott NA, Lam SC, Reik A, Zhou Y, Paschon DE, Li P, Wangzor T, Lee G, Zhang L, Rebar EJ. Nat Biotechnol. …

• Gene editing

July 31, 2019

Short-Acting Anti-VWF (von Willebrand Factor) Aptamer Improves the Recovery, Survival, and Hemostatic Functions of Refrigerated Platelets

Chen W, Voos KM, Josephson CD, Li R. Arterioscler Thromb Vasc Biol. 2019 Jul 18 PubMed

• Aptamer

The Arsenic Binding Aptamer Cannot Bind Arsenic: Critical Evaluation of Aptamer Selection and Binding

Zong C, Liu J. Anal Chem. 2019 Jul 25. PubMed

• Aptamer

Assay Determination by Mass Spectrometry for Oligonucleotide Therapeutics

Madsen M, Roussis S, Schniepp E, Rentel C, Capaldi D. Rapid Commun Mass Spectrom. 2019 Jul 6. PubMed

• Antisense/RNase H
• Medicinal Chemistry
• MicroRNA

Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models

Kim Y, Jo M, Schmidt J, Luo X, Prakash TP, Zhou T, Klein S, Xiao X, Post N, Yin Z, MacLeod AR. Mol Ther. 2019 Jun 29. pii: S1525-0016(19)30304-1. PubMed

• Antisense/RNase H
• Delivery