2025 Paper of the Year Award – Late Discovery Category
Michele Carrer, Ph.D. Executive Director, Department of Neurology Ionis Pharmaceuticals, Carlsbad, CA “Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles” https://doi.org/10.1093/nar/gkaf270 Biography: Michele Carrer, Ph.D., is an Executive Director in the Department of Neurology ...
2025 Paper of the Year – Basic Research Category
Ken Yamada, Ph.D. RTI, UMass Chan Medical School “Extended Nucleic Acid (exNA): A Novel Platform Technology Development for Enhancing siRNA Potency in Vivo” Paper of the Year: Enhancing siRNA efficacy in vivo with extended nucleic acid backbones https://doi.org/10.1038/s41587-024-02336-7 Biography: Dr. Ken Yamada is an ...
2024 Paper of the Year – Basic Research category
Dr. Mikyung Yu, Ph.D. Alnylam Pharmaceuticals Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates 2024 Paper of the Year – Basic Research category https://pubmed.ncbi.nlm.nih.gov/38742636/ Biography: Mikyung Yu, Ph.D., is a Principal Scientist in Research at Alnylam Pharmaceuticals. Dr. Yu led the ...
2023 Paper of the Year Award – Basic Research Category Winner Sonia Vallabh
Sonia Vallabh The Vallabh/Minikel Lab, The Broad Institute A single-cell map of antisense oligonucleotide activity in the brain https://pubmed.ncbi.nlm.nih.gov/36824749/
2023 Paper of the Year Award – Late Discovery Category Winner Jinkuk Kim, PhD
Jinkuk Kim, PhD KAIST - Korea Advanced Institute of Science and Technology A framework for individualized splice-switching oligonucleotide therapy https://pubmed.ncbi.nlm.nih.gov/37438524/ Biography: Jinkuk Kim is an Assistant Professor at KAIST in South Korea. He obtained a B.S. in computer science and a Ph.D. ...
2022 Paper of the Year Award – Basic Research Category
Tetsuya Nagata, Takanori Yokota, et al, Nature Biotechnology (2021). https://doi.org/10.1038/s41587-021-00972-x Takanori Yokota, MD, PhD Tokyo Medical and Dental University Biography: Dr. Yokota graduated from Tokyo Medical and Dental University in 1984 and completed his Residency and Fellowship in Musashino Red Cross Hospital ...
2022 Paper of the Year Award – Basic Research Category
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Kirk M. Brown, Martin A. Maier, Vasant Jadhav, et al, Nature Biotechnology (2022). https://doi.org/10.1038/s41587-022-01334-x Vasant Jadhav, PhD Alnylam Pharmaceuticals Biography: Vasant Jadhav is a Senior Vice President of Research at Alnylam Pharmaceuticals, where he ...
2021 Late Discovery Paper Of The Year Award – Winners
An mRNA Vaccine Against SARS-CoV-2 – Preliminary Report Phase I/II study of COVID-19 RNA vaccine BNT 162b1 in adults The need for platforms to develop vaccines rapidly and efficiently was clearly highlighted by the Covid-19 pandemic. The first vaccine against SARS-CoV-2 was approved only ...
2021 Basic Paper Of The Year Award – Winners
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates Givosiran, a GalNAc-conjugated siRNA, which was recently approved on the market, displays sustained knock-down over month-long periods. The following paper investigates the reasons behind those impressive pharmacodynamic properties. After looking into various mechanisms related to stability, accumulation or ...
Directed RNase H cleavage of nascent transcripts causes transcription termination
Lai F, Damle SS, Ling KK, Rigo F Read More
