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Traceless aptamer-mediated isolation of CD8+ T cells for chimeric antigen receptor T-cell therapy

• Paper of the Month

July 24, 2019

Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice

Aghajan M, Booten SL, Althage M, Hart CE, Ericsson A, Maxvall I, Ochaba J, Menschik-Lundin A, Hartleib J, Kuntz S, Gattis D, Ahlström C, Watt AT, Engelhardt JA, Monia BP, Magnone MC, Guo S. JCI Insight. 2019 Jun 20;4(12). PubMed

• Antisense/RNase H

June 30, 2019

Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington’s Disease

Imbert M, Blandel F, Leumann C, Garcia L, Goyenvalle A. Nucleic Acid Ther. 2019 Jun 11. PubMed

• Antisense/RNase H

Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells

Wang S, Allen N, Prakash TP, Liang XH, Crooke ST. Nucleic Acid Ther. 2019 Jun 3. PubMed

• Antisense/RNase H
• Delivery

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

Liang XH, Nichols JG, Hsu CW, Vickers TA, Crooke ST. Nucleic Acids Res. 2019 Jun 5. PubMed

• Antisense/RNase H