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A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming

Han J, LaVigne CA, Jones BT, Zhang H, Gillett F, Mendell JT. Science. 2020 Dec 18;370(6523):eabc9546. Pubmed

• MicroRNA
• Other papers of interest

February 16, 2021

The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation

Shi CY, Kingston ER, Kleaveland B, Lin DH, Stubna MW, Bartel DP. Science. 2020 Dec 18;370(6523):eabc9359. Pubmed

• MicroRNA
• Other papers of interest

Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition

Agirre E, Oldfield AJ, Bellora N, Segelle A, Luco RF. Nat Commun. 2021 Jan 29;12(1):682. Pubmed

• Alternative splicing
• Other papers of interest

The administration of antisense oligonucleotide golodirsen reduces pathological regeneration in patients with Duchenne muscular dystrophy

Scaglioni D, Catapano F, Ellis M, Torelli S, Chambers D, Feng L, Beck M, Sewry C, Monforte M, Harriman S, Koenig E, Malhotra J, Popplewell L, Guglieri M, Straub V, Mercuri E, Servais L, Phadke R, Morgan J, Muntoni Acta …

• Alternative splicing
• Clinical Development

Safety, Pharmacokinetic and Pharmacodynamic Evaluation of a 2′-MOE Antisense Oligonucleotide-GalNAc3 Conjugate that Targets the Human Transmembrane Protease Serine 6 (TMPRSS6)

• Antisense/RNase H
• Toxicology