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A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

• Antisense/RNase H
• Long noncoding RNA

February 29, 2020

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

• Anti-miR/antagomir
• MicroRNA

Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy

• Alternative splicing
• Splice modulation

Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model

• Alternative splicing
• Medicinal Chemistry
• Splice modulation

Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy

Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F. J Cachexia Sarcopenia Muscle. 2020 Feb 7. PubMed

• Alternative splicing
• Splice modulation