2020 Dr. Alan M. Gewirtz Memorial Scholarship Award Winner Chantal M. Ferguson
Chantal M. Ferguson, RNA Therapeutics Institute, University of Massachusetts Medical School RNAi modulation of APOE as a potential therapeutic for Alzheimer Disease Biography: Chantal joined the Khvorova Lab in 2017 with an interest in developing new tools to understand and treat neurological disorders. Her ...
Directed RNase H cleavage of nascent transcripts causes transcription termination
Lai F, Damle SS, Ling KK, Rigo F Read More
Inclisiran for the treatment of heterozygous familial hyper-cholesterolemia (Raal et al., 2020)
Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP; ORION-9 Investigators. Lee JS, Mendell JT. Read More
Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination.
Lee JS, Mendell JT. Mol Cell. 2020 Jan 2. pii: S1097-2765(19)30924-4. PubMed
2019 OTS Travel Grant Recipients
Leonora Abdullahu, McGill University Osama Ahmed, Karolinska Institutet Julia Alterman, RNA Therapeutics Institute, UMass Medical School Daniela Araújo, Centre of Biological Engineering Christopher Barkau, Southern Illinois University School of Medicine Ivan Chernikov, Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy ...
2019 OTS Young Investigator Award Winner Holly Kordasiewicz, PhD
Holly Kordasiewicz, PhD Ionis Pharmaceuticals Biography: Dr. Holly Kordasiewicz is an Executive Director in the Neuroscience Drug Discovery Departments at Ionis Pharmaceuticals. Holly heads a team focused on identifying antisense oligonucleotide therapeutics for neurodegenerative diseases, including drugs now in clinical trials for ALS, Alzheimer’s disease, ...
2019 OTS Lifetime Achievement Award Winner Muthiah (Mano) Manoharan
Muthiah (Mano) Manoharan, Ph.D Alnylam Pharmaceuticals Muthiah (Mano) Manoharan serves as a Senior Vice President, a Scientific Advisory Board Member, and a Distinguished Research Scientist at Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA. In 2003, he was the first chemist hired at Alnylam. He and his ...
2019 Dr. Alan M. Gewirtz Memorial Scholarship Winner: Bruno M.D.C. Godinho, PhD
Bruno M.D.C. Godinho, PhD RNA Therapeutics Institute, UMass Medical School Biography: Bruno Godinho received his PhD in Pharmacy from University College Cork (Ireland) in 2014, where he studied formulation-based approaches for siRNA delivery to the central nervous system (CNS). His work from graduate school ...
2018 OTS Lifetime Achievement Award Winner Marvin H. Caruthers
Marvin H. Caruthers Distinguished Professor of Chemistry University of Colorado Boulder, Colorado Marvin H. Caruthers is a Distinguished Professor of Biochemistry and Chemistry at the University of Colorado, Boulder. A Guggenheim Fellow, Dr. Caruthers received his B.S. in Chemistry from Iowa State University, his Ph.D. ...
2018 OTS Poster Award Winners
001 Bruno Godinho, University of Massachusetts Medical School Neuroactive siRNA Scaffold Enables Broad Distribution and Robust Gene Silencing Throughout the Central Nervous System: Preclinical Studies in Large Mammals 002 Julia Alterman, University of Massachusetts Medical School Potent and long-term RNA interference-based silencing of huntingtin expression ...
