Modulation of BACE1 activity by chemically modified aptamers
Gasse C, Zaarour M, Noppen S, Abramov M, Marlière P, Liekens S, De Strooper B, Herdewijn P. Chembiochem. 2018 Jan 11. PubMed
A modular platform for targeted RNAi therapeutics
Kedmi R, Veiga N, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N, Hazan-Halevy I, Nahary L, Leviatan-Ben-Arye S, Harlev M, Behlke M, Benhar I, Lieberman J, Peer D. Nat Nanotechnol. 2018 Jan 29. PubMed
Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
Gibori H, Eliyahu S, Krivitsky A, Ben-Shushan D, Epshtein Y, Tiram G, Blau R, Ofek P, Lee JS, Ruppin E, Landsman L, Barshack I, Golan T, Merquiol E, Blum G, Satchi-Fainaro R. Nat Commun. 2018 Jan 2;9(1):16. PubMed
Nanotherapeutics for Gene Modulation that Prevents Apoptosis in the Brain and Fatal Neuroinflammation
Kim SS, Rait A, Garrido-Sanabria ER, Pirollo KF, Harford JB, Chang EH. Mol Ther. 2018 Jan 3;26(1):84-94. PubMed
Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma
Zhu M, Ding X, Zhao R, Liu X, Shen H, Cai C, Ferrari M, Wang HY, Wang RF. J Control Release. 2018 Jan 8;272:72-82. PubMed
Eradication of spontaneous malignancy by local immunotherapy
Sagiv-Barfi I, Czerwinski DK, Levy S, Alam IS, Mayer AT, Gambhir SS, Levy R. Sci Transl Med. 2018 Jan 31;10(426). PubMed
B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors
Zhao X, Zhang Z, Moreira D, Su YL, Won H, Adamus T, Dong Z, Liang Y, Yin HH, Swiderski P, Pillai RK, Kwak L, Forman S, Kortylewski M. Mol Ther. 2018 Jan 17. pii: S1525-0016(18)30014-5. PubMed
Acute hepatotoxicity of 2′ fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins
Shen W, De Hoyos CL, Sun H, Vickers TA, Liang XH, Crooke ST. Nucleic Acids Res. 2018 Jan 30. PubMed
The Evaluation of Pharmacodynamics and Pharmacokinetics of Anti-thrombin DNA Aptamer RA-36
Zavyalova E, Samoylenkova N, Revishchin A, Turashev A, Gordeychuk I, Golovin A, Kopylov A, Pavlova G. Front Pharmacol. 2017 Dec 14;8:922. PubMed
A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells
Wang S, Xiao Y, Zhang DD, Wong PK. Biomaterials. 2018 Feb;156:56-64. PubMed
