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How to Develop and Prove High-Efficiency Selection of Ligands from Oligonucleotide Libraries: A Universal Framework for Aptamers and DNA-Encoded Small-Molecule Ligands

Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.

• Aptamer
• Reviews

April 23, 2021

Super-resolution RNA imaging using a rhodamine-binding aptamer with fast exchange kinetics

Sunbul M, Lackner J, Martin A, Englert D, Hacene B, Grün F, Nienhaus K, Nienhaus GU, Jäschke A. Nat Biotechnol. 2021 Feb 11. Pubmed

• Aptamer
• circRNA
• Clinical Development
• mRNA
• Other papers of interest
• Pre-Clinical Research

March 15, 2021

Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes

Han D, Miao Y, Gao Q, Mao M, Zhang C, Yang L, Yang Y. Angew Chem Int Ed Engl. 2021 Feb 25 Pubmed

• Aptamer

Targeted suicide gene therapy for liver cancer based on ribozyme-mediated RNA replacement through post-transcriptional regulation

Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.

• Aptamer
• Gene editing
• MicroRNA
• Ribozyme

April 23, 2021

A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome

Papers of interest to society members in the field of oligonucleotide therapeutics. Antisense, aptamers, lncRNA, siRNA, splice modulation and ribozymes.

• Alternative splicing
• Splice modulation