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Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA
Baronti L, Guzzetti I, Ebrahimi P, Friebe Sandoz S, Steiner E, Schlagnitweit J, Fromm B, Silva L, Fontana C, Chen AA, Petzold K. Nature. 2020 May 27. Pubmed
May 15, 2020
Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease
Wooddell CI, Blomenkamp K, Peterson RM, Subbotin VM, Schwabe C, Hamilton J, Chu Q, Christianson DR, Hegge JO, Kolbe J, Hamilton HL, Branca-Afrazi MF, Given BD, Lewis DL, Gane E, Kanner SB, Teckman JH. JCI Insight. 2020 May 7:135348. Pubmed
Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles
Moitra P, Alafeef M, Dighe K, Frieman M, Pan D. ACS Nano. 2020 May 28:acsnano.0c03822. Pubmed
Interview with Amalia Sapag, PhD
Science: Q: Paul Zamecnik and Mary Stephenson in 1978 reported the very first studies on antisense mechanisms of gene silencing. Since the inception of this field – how far have we come – both in basic and therapeutic research & development? A: The original antisense mechanism has been joined
June 2, 2020
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