Advances in SELEX technologies for aptamer selection
Presenter: Günter Mayer, University of Bonn, Germany Date: August 27, 2019 Description: Aptamers are short single-stranded oligonucleotides, selected to interact with target molecules with high affinity and specificity. These characteristics and their versatile applicability, make aptamers universal molecular probes in biotechnological and therapeutic applications. ...
Interview with Kalyan Dulla, PhD, MBA
Kalyan Dulla, PhD, MBA Director Non-Clinical Research ProQR Therapeutics How did you become interested in the field of oligonucleotides? Although I had been aware of the use of antisense oligonucleotides for (m)RNA knockdown or as aptamers since my university days I was not ...
Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides To Reverse Chemoresistance
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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
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5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger
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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
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Duplex RNAs and ss-siRNAs Block RNA Foci Associated with Fuchs’ Endothelial Corneal Dystrophy
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A microRNA-inducible CRISPR-Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool
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MicroRNA-21-5p as a novel therapeutic target for osteoarthritis
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Gain-of-function mutation of microRNA-140 in human skeletal dysplasia
Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz ZU, Ayturk UM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, Eyre DR, Warman ML, Nishimura G, Sharp PA, Kobayashi T. Nat Med. 2019 Apr;25(4):583-590. PubMed
