Webinars2025-06-09T14:46:17+00:00

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Past Webinars

5June, 2020

Time matters! – Why PK/PD is important for oligo development

Categories: Past Webinars|

Presenter: Carl Amilon (AstraZeneca) Date: June 10, 2020 Description: This webinar will give an overview of how incorporating quantitative PK/PD aspects of an oligonucleotide will help you designing more informative experiments and help in translating to a human. We have all struggled with questions around the expectations of a study outcome ...

1April, 2020

Safety of Therapeutic Oligonucleotides

Categories: Past Webinars|

Presenter: Patrik Andersson (AstraZeneca) Date: May 13, 2020 Description: Successful therapeutics need to be efficacious and safe. Although oligonucleotide therapeutics act via unique mechanisms, they follow the same principles for safety assessment as other modalities. This webinar will give an overview of these principles and what needs to be considered from ...

11December, 2019

Delivery of Macromolecular Therapeutics: Tackling a Billion Year Old Barrier

Categories: Past Webinars|

Presenter: Steven Dowdy (UCSD School of Medicine) Date: December 17, 2019 Description: All macromolecular therapeutics, including ASOs, siRNAs, peptides, proteins, CRISPR, mRNA and non-viral DNA vectors, are taken up into cells by endocytosis. However, <1% to none of the endocytosed therapeutic cargo escapes into the cytoplasm and nucleus of the cell. ...

20November, 2019

Circular RNA Immunity

Categories: Past Webinars|

Presenter: Grace Chen (Yale School of Medicine) Date: March 25, 2020 Description: Circular RNAs are a newly appreciated class of ubiquitous and abundant RNAs. In the webinar, we will cover biological and chemical approaches to synthesize circular RNAs, how cells distinguish between endogenous and foreign circular RNAs, and properties of circular RNAs ...

19November, 2019

Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Categories: Past Webinars|

Presenter: Robert MacLeod (Ionis Pharmaceuticals) Date: February 26, 2020 Recording of the webinar: Click play to view Presenter Biography Robert MacLeod (Ionis Pharmaceuticals) Dr. MacLeod is currently the Vice President Oncology Research and Development, and Franchise ...

30September, 2019

Patient Representative Webinar

Categories: Past Webinars|

Presenter: Daniel O’Reilly and Joseph Ochaba (Oligonucleotide Therapeutics Society) Date: November 19, 2019 Description: With a constantly growing list of oligonucleotide therapies that are entering the clinics, these exciting research molecules-turned-therapeutic strategy are starting to lead the way in treatments for many devastating diseases. At their core, an Oligonucleotide ...

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