Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs
Chen X, Zhang D, Su N, Bao B, Xie X, Zuo F, Yang L, Wang H, Jiang L, Lin Q, Fang M, Li N, Hua X, Chen Z, Bao C, Xu J, Du W, Zhang L, Zhao Y, Zhu L, Loscalzo J, Yang Y. Nat ...
Lipid-based nanoparticle formulations for small molecules and RNA drugs
Ickenstein LM, Garidel P. Expert Opin Drug Deliv. 2019 Sep 17. PubMed
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, ...
Quantification Methods for oligonucleotide therapeutics in serum and tissue
Presenter: Mai Thayer, Amgen, USA Date: October 8, 2019 Description: Oligonucleotides are a quickly evolving modality with strong proof of concept established in the clinic. Despite the clinical success of oligonucleotides, there is still limited understanding of ADME (absorption, disposition, metabolism and excretion) in ...
Interview with Jessica Rouge, PhD
Jessica Rouge, Ph.D., Assistant Professor Chemistry Department University of Connecticut How did you become interested in the field of oligonucleotides? One day I participated in a weekend biotechnology class at a community college that was designed for high school students where I ran a ...
Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease
Lee J, Pinares-Garcia P, Loke H, Ham S, Vilain E, Harley VR. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16577-16582. PubMed
Phosphorothioate Antisense Oligonucleotides Bind P-Body Proteins and Mediate P-Body Assembly
Wang Y, Shen W, Liang XH, Crooke ST. Nucleic Acid Ther. 2019 Aug 20. PubMed
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, Sena-Esteves ...
Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway
Uroda T, Anastasakou E, Rossi A, Teulon JM, Pellequer JL, Annibale P, Pessey O, Inga A, Chillón I, Marcia M. Mol Cell. 2019 Aug 15. PubMed
miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease
Hu YB, Zhang YF, Wang H, Ren RJ, Cui HL, Huang WY, Cheng Q, Chen HZ, Wang G. Cell Death Dis. 2019 Aug 5;10(8):589. PubMed
