Leveraging Nature’s Carrier: Albumin-Binding Dendritic siRNA for Enhanced Tumor Targeting
Small interfering RNA (siRNA) therapeutics are rapidly reshaping the landscape of precision medicine, offering the ability to silence disease-driving genes with exceptional specificity and durability. However, due to delivery barriers, the promise of siRNA therapy has largely been confined to the liver. Recent advances ...
Newly Approved Drug Shows Clinical and Quality-of-Life Improvements for HAE Patients
Emily Wheeler was 19 when she noticed a gradual swelling in her left foot. Believing it was an allergic reaction, she went to her doctor, who told her it was gout and gave her several pills. An hour later, she started vomiting uncontrollably and ...
BLADE Directed Evolution of SaCas9 gRNAs Improves Gene Editing Efficiency
Date: December 11, 2025Time: 11-12pm EST / 5-6pm CET Register Here Title: BLADE Directed Evolution of SaCas9 gRNAs Improves Gene Editing Efficiency Description: CRISPR-Cas9 efficiency is often limited by misfolding between the sgRNA scaffold and spacer regions. Using the BLADE-SELEX directed evolution platform, we ...
Trainee Spotlight Series: 2025 Oligo Meeting Poster Winners 1
Date: December 4, 2025 Time: 11-12pm EST / 5-6pm CET Register Here Title: Trainee Spotlight Series: 2025 Oligo Meeting Poster Winners 1 Description: Join us for this Trainee Spotlight webinar featuring trainees who won poster awards at the 2025 OTS Annual Meeting. ...
New Approaches for Functional Oligonucleotides: RNA Activation and Non-Nucleosidic Aptamers.
Date: November 20, 2025Time: 11-12pm EST / 5-6pm CET Register Here Title: New Approaches for Functional Oligonucleotides: RNA Activation and Non-Nucleosidic Aptamers Description: This talk will highlight two complementary approaches aimed at expanding the functional scope of oligonucleotide therapeutics. First, I will present ...
DNA-based tools for the study and treatment of Parkinson’s Disease
Date: November 6, 2025 Time: 11-12pm EST / 5-6pm CET Title: DNA-based tools for the study and treatment of Parkinson’s Disease Description: Aptamers are short stretches of DNA that fold into 3-dimensional shapes that can act as pockets for binding other ...
OTS Member Highlight – Dr. Richard Geary
Dr. Richard Geary, current OTS President, has always been passionate about health and finding ways to improve people's well-being. Born with a rare disease, he was in the medical spotlight at a young age; now, he’s known for his incredible contributions to the scientific ...
Binding and Ligand Activation Driven Enrichment–Directed Evolution of SaCas9 gRNAs Improves Gene Editing Efficiency
Authors: Telmo Llanga, Korie Bush, Ying Sun, Amy Yan, Jonathan Zhou, Jan Gorodkin, and Bruce A. Sullenger AbstractClustered regularly interspaced short palindromic repeats-based editing is inefficient at over two-thirds of genetic targets. A primary cause is ribonucleic acid (RNA) misfolding that can occur between the ...
2025 President’s Special Award
David Corey, Ph.D. UT Southwestern Medical Center Biography: Dr. Corey received his BA from Harvard in 1985 and his PhD from UC Berkeley in 1990 under the guidance of Dr. Peter Schultz. After postdoctoral study in the laboratory of Dr. Charles Craik at UCSF, ...
2025 Paper of the Year Award – Late Discovery Category
Michele Carrer, Ph.D. Executive Director, Department of Neurology Ionis Pharmaceuticals, Carlsbad, CA “Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles” https://doi.org/10.1093/nar/gkaf270 Biography: Michele Carrer, Ph.D., is an Executive Director in the Department of Neurology ...
