OTS Member Highlight – Dr. Rebecca Miles
The incoming OTS President, Dr. Rebecca Miles, has always been curious about the way things work, and in high school, a human anatomy and physiology class sparked her passion for researching human diseases. As the first person in her family to pursue higher education, she ...
Extended Nucleic Acid Therapeutics: Unlocking potential through tiny methylene chemical modifications
Date: April 2, 2026Time: 11-12pm EDT / 5-6pm CEST Register Here Title: Extended Nucleic Acid Therapeutics: Unlocking potential through tiny methylene chemical modifications Description: Modulation of the backbone structures of oligonucleotides has a profound impact on the pharmacokinetics and pharmacodynamics of RNA medicines. In ...
Small Nuclear RNAs (snRNAs) Enhance RNA Base Editing
Gene editing technologies are transforming molecular medicine, offering unprecedented potential to treat — and even cure — a range of genetic disorders. However, as tools like CRISPR enter clinical settings, concerns about its safety, specificity, and long-term side effects, such as off-target edits or ...
Advancing Prime Editing–Based Genome Editing Technologies for Therapeutic Applications
Date: March 26, 2026 Time: 12-1pm EDT / 5-6pm CET Register Here Title: Advancing Prime Editing–Based Genome Editing Technologies for Therapeutic Applications Description: In this webinar, I will discuss recent advances in prime editing–based genome engineering, including split prime editing, template-jumping prime ...
Trainee Spotlight Series: 2025 Oligo Meeting Poster Winners 4
Date: March 12, 2026 Time: 12-1pm EDT / 5-6pm CET Register Here Title: Neonatal Delivery of Exon Skipping Therapeutics Maximizes Brain Dystrophin Rescue in the Mdx52 Mouse Model of DMD Description: In this webinar, I will explore how early-life exon-skipping strategies can ...
Trainee Spotlight Series: 2025 Oligo Meeting Poster Winners 3
Date: February 26, 2026 Time: 11am-12pm EST / 5-6pm CET Register Here Title: Combinational modulation of DNA Mismatch Repair protein ratios alter CAG repeat instability in hTERT-RPE1 cellular model Description: The somatic expansion of an unstable CAG trinucleotide repeat tract located within ...
Where Chemistry Meets Purpose
Date: February 12, 2026 Time: 11am-12pm EST / 5-6pm CET Register Here Title: Where Chemistry Meets Purpose Description: Sonja will share her journey through academia, industry, pharma, consulting, and now entrepreneurship as she drives Livinovea in the life sciences. What began over ...
Acute CNS Responses to centrally Delivered Oligonucleotides
Date: January 29, 2026Time: 11am-12pm EST / 5-6pm CET Register Here Title: Acute CNS Responses to centrally Delivered Oligonucleotides Description: Oligonucleotides delivered into cerebrospinal fluid elicit two independent, short-lived CNS phenotypes: an immediate neuronal activation phenotype that appears within minutes and resolves ...
Trainee Spotlight Series: 2025 Oligo Meeting Poster Winners 2
Date: January 15, 2026 Time: 11am-12pm EST / 5-6pm CET Register Here Title: Sustained muscle function improvement after a single in vivo dose of antibody oligonucleotide conjugate (AOC) in the mdx mouse model for Duchenne muscular dystrophy Description: Duchenne muscular dystrophy results ...
Leveraging Nature’s Carrier: Albumin-Binding Dendritic siRNA for Enhanced Tumor Targeting
Small interfering RNA (siRNA) therapeutics are rapidly reshaping the landscape of precision medicine, offering the ability to silence disease-driving genes with exceptional specificity and durability. However, due to delivery barriers, the promise of siRNA therapy has largely been confined to the liver. Recent advances ...
