Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing
Liu S, Cheng Q, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ. Nat Mater. 2021 Feb 4. Pubmed
Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs
Li Y, Chen X, Jin R, Chen L, Dang M, Cao H, Dong Y, Cai B, Bai G, Gooding JJ, Liu S, Zou D, Zhang Z, Yang C. Sci Adv. 2021 Feb 24;7(9):eabd6740. Pubmed
A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery
Munson MJ, O'Driscoll G, Silva AM, Lázaro-Ibáñez E, Gallud A, Wilson JT, Collén A, Esbjörner EK, Sabirsh A. Commun Biol. 2021 Feb 16;4(1):211. Pubmed
A self-catabolic multifunctional DNAzyme nanosponge for programmable drug delivery and efficient gene silencing
Wang J, Yu S, Wu Q, Gong X, He S, Shang J, Liu X, Wang F. Angew Chem Int Ed Engl. 2021 Feb 18. Pubmed
Centyrin ligands for extrahepatic delivery of siRNA.
Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Mendrola Zarazowski J, Jadhav V, Maier MA, Sepp-Lorenzino L, O'Neil K, Dudkin V. Mol Ther. 2021 Feb 15:S1525-0016(21)00082-4. Pubmed
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell
Knerr L, Prakash TP, Lee R, Drury Iii WJ, Nikan M, Fu W, Pirie E, Maria L, Valeur E, Hayen A, Ölwegård-Halvarsson M, Broddefalk J, Ämmälä C, Østergaard ME, Meuller J, Sundström L, Andersson P, Janzén D, Jansson-Löfmark R, Seth PP, Andersson S. J Am ...
siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, Manoharan M. Nucleic Acids Res. 2021 Feb 12 Pubmed
Perspectives on the Designation of Oligonucleotide Starting Materials
Kiesman WF, McPherson AK, Diorazio LJ, Van den Bergh L, Smith PD, Northall JM, Fettes A, Wang T, Mehlmann M, Raza S, Held G. Nucleic Acid Ther. 2021 Feb 2. Pubmed
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Vasquez G, Freestone GC, Wan WB, Low A, De Hoyos CL, Yu J, Prakash TP, Ǿstergaard ME, Liang XH, Crooke ST, Swayze EE, Migawa MT, Seth PP. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. Pubmed
Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes
Han D, Miao Y, Gao Q, Mao M, Zhang C, Yang L, Yang Y. Angew Chem Int Ed Engl. 2021 Feb 25 Pubmed
