Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination.
Lai F, Damle SS, Ling KK, Rigo F. Mol Cell. 2020 Jan 3. pii: S1097-2765(19)30959-1. PubMed
Interview with Marcin Kortylewski, PhD
Marcin Kortylewski, Ph.D. Associate Professor Department of Immuno-Oncology Beckman Research Institute City of Hope National Medical Center How did you become interested in the field of oligonucleotides? Rather late, after about ten years of graduate and postdoctoral research on signal transduction and tumor immunology ...
mRNA Structure Regulates Protein Expression Through Changes in Functional Half-Life
Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. Melissa J. Moore Iain J. McFadyen ...
RNA Splicing by the Spliceosome.
Wilkinson ME, Charenton C, Nagai K. Annu Rev Biochem. 2019 Dec 3. PubMed
A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo.
Zhong G, Wang H, He W, Li Y, Mou H, Tickner ZJ, Tran MH, Ou T, Yin Y, Diao H, Farzan M. Nat Biotechnol. 2019 Dec 23. PubMed
mRNA structure regulates protein expression through changes in functional half-life.
Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. PubMed
HER3-targeted protein chimera forms endosomolytic capsomeres and self-assembles into stealth nucleocapsids for systemic tumor homing of RNA interference in vivo.
Alonso-Valenteen F, Pacheco S, Srinivas D, Rentsendorj A, Chu D, Lubow J, Sims J, Miao T, Mikhael S, Hwang JY, Abrol R, Medina Kauwe LK. Nucleic Acids Res. 2019 Dec 2;47(21):11020-11043. PubMed
Aptamers as Reversible Sorting Ligands for Preparation of Cells in Their Native State.
Gray BP, Requena MD, Nichols MD, Sullenger BA. Cell Chem Biol. 2019 Dec 21. pii: S2451-9456(19)30400-3. PubMed
Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε.
Zumrut H, Yang Z, Williams N, Arizala JDR, Batool S, Benner S, Mallikaratchy P. Biochemistry. 2019 Dec 27. PubMed
Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides.
Scharner J, Ma WK, Zhang Q, Lin KT, Rigo F, Bennett CF, Krainer AR. Nucleic Acids Res. 2019 Dec 5. PubMed
