Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice
Klein AF, Varela MA, Arandel L, Holland A, Naouar N, Arzumanov A, Seoane D, Revillod L, Bassez G, Ferry A, Jauvin D, Gourdon G, Puymirat J, Gait MJ, Furling D, Wood MJ. J Clin Invest. 2019 Sep 30. Joint First Authors Klein ...
Interview with Peter A. Beal, PhD
Peter A. Beal, Ph.D., Professor Department of Chemistry University of California, Davis How did you become interested in the field of oligonucleotides? My interests in therapeutic oligonucleotides can be traced back to my time as an undergraduate student at the University of North Dakota. ...
2019 OTS Travel Grant Recipients
Leonora Abdullahu, McGill University Osama Ahmed, Karolinska Institutet Julia Alterman, RNA Therapeutics Institute, UMass Medical School Daniela Araújo, Centre of Biological Engineering Christopher Barkau, Southern Illinois University School of Medicine Ivan Chernikov, Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy ...
Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging
Mazur C, Powers B, Zasadny K, Sullivan JM, Dimant H, Kamme F, Hesterman J, Matson J, Oestergaard M, Seaman M, Holt RW, Qutaish M, Polyak I, Coelho R, Gottumukkala V, Gaut CM, Berridge M, Albargothy NJ, Kelly L, Carare RO, Hoppin J, Kordasiewicz H, Swayze ...
A novel and translational role for autophagy in antisense oligonucleotide trafficking and activity
Ochaba J, Powers AF, Tremble KA, Greenlee S, Post NM, Matson JE, MacLeod AR, Guo S, Aghajan M. Nucleic Acids Res. 2019 Oct 15. PubMed
Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice
Shirai T, Revenko AS, Tibbitts J, Ngo ATP, Mitrugno A, Healy LD, Johnson J, Tucker EI, Hinds MT, Coussens LM, McCarty OJT, Monia BP, Gruber A. Blood Adv. 2019 Oct 22;3(20):3080-3091. PubMed
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency
Chen CJ, Sgritta M, Mays J, Zhou H, Lucero R, Park J, Wang IC, Park JH, Kaipparettu BA, Stoica L, Jafar-Nejad P, Rigo F, Chin J, Noebels JL, Costa-Mattioli M. Nat Med. 2019 Oct 21. PubMed
Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target
Veiga N, Goldsmith M, Diesendruck Y, Ramishetti S, Rosenblum D, Elinav E, Behlke MA, Benhar I, Peer D. J Control Release. 2019 Oct 18;313:33-41. PubMed
The RNA-RNA base pairing potential of human Dicer and Ago2 proteins
Pokornowska M, Milewski MC, Ciechanowska K, Szczepańska A, Wojnicka M, Radogostowicz Z, Figlerowicz M, Kurzynska-Kokorniak A. Cell Mol Life Sci. 2019 Oct 26. PubMed
LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma
Xu Y, Li Y, Jin J, Han G, Sun C, Pizzi MP, Huo L, Scott A, Wang Y, Ma L, Lee JH, Bhutani MS, Weston B, Vellano C, Yang L, Lin C, Kim Y, MacLeod AR, Wang L, Wang Z, Song S, Ajani JA. Mol ...
