Evolutionary Outcomes of Diversely-Functionalized Aptamers Isolated from In Vitro Evolution.
Kong D, Movahedi M, Mahdavi-Amiri Y, Yeung W, Tiburcio TR, Chen D, Hili R. ACS Synth Biol. 2019 Nov 27. PubMed
Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition.
Kwon PS, Ren S, Kwon SJ, Kizer ME, Kuo L, Xie M, Zhu D, Zhou F, Zhang F, Kim D, Fraser K, Kramer LD, Seeman NC, Dordick JS, Linhardt RJ, Chao J, Wang X. Nat Chem. 2019 Nov 25. PubMed
Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome.
Aguado J, Sola-Carvajal A, Cancila V, Revêchon G, Ong PF, Jones-Weinert CW, Wallén Arzt E, Lattanzi G, Dreesen O, Tripodo C, Rossiello F, Eriksson M, d'Adda di Fagagna F. Nat Commun. 2019 Nov 18;10(1):4990. PubMed
Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.
Liu Z, Johnson ST, Zhang Z, Corey DR. Nucleic Acid Ther. 2019 Oct 31. . PubMed
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease
Kim J, Hu C, Moufawad El Achkar C, Black LE, Douville J, Larson A, Pendergast MK, Goldkind SF, Lee EA, Kuniholm A, Soucy A, Vaze J, Belur NR, Fredriksen K, Stojkovska I, Tsytsykova A, Armant M, DiDonato RL, Choi J, Cornelissen L, Pereira LM, ...
Circular RNA Immunity
Presenter: Grace Chen (Yale School of Medicine) Date: March 25, 2020 Description: Circular RNAs are a newly appreciated class of ubiquitous and abundant RNAs. In the webinar, we will cover biological and chemical approaches to synthesize circular RNAs, how cells distinguish between endogenous and foreign circular RNAs, ...
Antisense Oligonucleotides- Mechanisms of Action and Rational Design
Presenter: Robert MacLeod (Ionis Pharmaceuticals) Date: February 26, 2020 Recording of the webinar: Click play to view Presenter Biography Robert MacLeod (Ionis Pharmaceuticals) Dr. MacLeod is currently the Vice President Oncology ...
Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice
Klein AF, Varela MA, Arandel L, Holland A, Naouar N, Arzumanov A, Seoane D, Revillod L, Bassez G, Ferry A, Jauvin D, Gourdon G, Puymirat J, Gait MJ, Furling D, Wood MJ. J Clin Invest. 2019 Sep 30. Joint First Authors Klein ...
Interview with Peter A. Beal, PhD
Peter A. Beal, Ph.D., Professor Department of Chemistry University of California, Davis How did you become interested in the field of oligonucleotides? My interests in therapeutic oligonucleotides can be traced back to my time as an undergraduate student at the University of North Dakota. ...
2019 OTS Travel Grant Recipients
Leonora Abdullahu, McGill University Osama Ahmed, Karolinska Institutet Julia Alterman, RNA Therapeutics Institute, UMass Medical School Daniela Araújo, Centre of Biological Engineering Christopher Barkau, Southern Illinois University School of Medicine Ivan Chernikov, Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy ...
