Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs
Gagnon KT, Corey DR. Nucleic Acid Ther. 2019 Mar 23. PubMed
Re-Engineering RNA Molecules into Therapeutic Agents
Egli M, Manoharan M. Acc Chem Res. 2019 Mar 26. PubMed
Chemical methods for the modification of RNA
Flamme M, McKenzie LK, Sarac I, Hollenstein M. Methods. 2019 Mar 21. pii: S1046-2023(18)30274-3. PubMed
Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria
Sardh E, Harper P, Balwani M, Stein P, Rees D, Bissell DM, Desnick R, Parker C, Phillips J, Bonkovsky HL, Vassiliou D, Penz C, Chan-Daniels A, He Q, Querbes W, Fitzgerald K, Kim JB, Garg P, Vaishnaw A, Simon AR, Anderson KE. N Engl J ...
2019 Dr. Alan M. Gewirtz Memorial Scholarship Winner: Bruno M.D.C. Godinho, PhD
Bruno M.D.C. Godinho, PhD RNA Therapeutics Institute, UMass Medical School Biography: Bruno Godinho received his PhD in Pharmacy from University College Cork (Ireland) in 2014, where he studied formulation-based approaches for siRNA delivery to the central nervous system (CNS). His work from graduate school ...
Interview with Daniel O’Reilly, PhD Candidate
Daniel O’Reilly MChem, PhD Candidate McGill University How did you become interested in the field of oligonucleotides? My introduction to the world of genetic disease and oligonucleotides came at an early age when my mum was diagnosed with Huntington’s Disease (HD). Witnessing the ...
Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
Lindén D, Ahnmark A, Pingitore P, Ciociola E, Ahlstedt I, Andréasson AC, Sasidharan K, Madeyski-Bengtson K, Zurek M, Mancina RM, Lindblom A, Bjursell M, Böttcher G, Ståhlman M, Bohlooly-Y M, Haynes WG, Carlsson B, Graham M, Lee R, Murray S, Valenti L, Bhanot S, Åkerblad ...
CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury
Joy MT, Ben Assayag E, Shabashov-Stone D, Liraz-Zaltsman S, Mazzitelli J, Arenas M, Abduljawad N, Kliper E, Korczyn AD, Thareja NS, Kesner EL, Zhou M, Huang S, Silva TK, Katz N, Bornstein NM, Silva AJ, Shohami E, Carmichael ST. Cell. 2019 Feb 21;176(5):1143-1157.e13. PubMed
Targeting miR-34a/Pdgfra interactions partially corrects alveologenesis in experimental bronchopulmonary dysplasia
Ruiz-Camp J, Quantius J, Lignelli E, Arndt PF, Palumbo F, Nardiello C, Surate Solaligue DE, Sakkas E, Mižíková I, Rodríguez-Castillo JA, Vadász I, Richardson WD, Ahlbrecht K, Herold S, Seeger W, Morty RE. EMBO Mol Med. 2019 Feb 15. PubMed
In vivo RNA editing of point mutations via RNA-guided adenosine deaminases
Katrekar D, Chen G, Meluzzi D, Ganesh A, Worlikar A, Shih YR, Varghese S, Mali P. Nat Methods. 2019 Mar;16(3):239-242. PubMed
