Acute CNS Responses to centrally Delivered Oligonucleotides
Date: January 29, 2026Time: 11am-12pm EST / 5-6pm CET Register Here Title: Acute CNS Responses to centrally Delivered Oligonucleotides Description: Oligonucleotides delivered into cerebrospinal fluid elicit two independent, short-lived CNS phenotypes: an immediate neuronal activation phenotype that appears within minutes and resolves ...
Trainee Spotlight Series: 2025 Oligo Meeting Poster Winners 2
Date: January 15, 2026 Time: 11am-12pm EST / 5-6pm CET Title: Sustained muscle function improvement after a single in vivo dose of antibody oligonucleotide conjugate (AOC) in the mdx mouse model for Duchenne muscular dystrophy Description: Duchenne muscular dystrophy results from ...
Leveraging Nature’s Carrier: Albumin-Binding Dendritic siRNA for Enhanced Tumor Targeting
Small interfering RNA (siRNA) therapeutics are rapidly reshaping the landscape of precision medicine, offering the ability to silence disease-driving genes with exceptional specificity and durability. However, due to delivery barriers, the promise of siRNA therapy has largely been confined to the liver. Recent advances ...
Newly Approved Drug Shows Clinical and Quality-of-Life Improvements for HAE Patients
Emily Wheeler was 19 when she noticed a gradual swelling in her left foot. Believing it was an allergic reaction, she went to her doctor, who told her it was gout and gave her several pills. An hour later, she started vomiting uncontrollably and ...
BLADE Directed Evolution of SaCas9 gRNAs Improves Gene Editing Efficiency
Date: December 11, 2025 Time: 11-12pm EST / 5-6pm CET Title: BLADE Directed Evolution of SaCas9 gRNAs Improves Gene Editing Efficiency Description: CRISPR-Cas9 efficiency is often limited by misfolding between the sgRNA scaffold and spacer regions. Using the BLADE-SELEX directed evolution ...
Trainee Spotlight Series: 2025 Oligo Meeting Poster Winners 1
Date: December 4, 2025 Time: 11-12pm EST / 5-6pm CET Title: Enhancing mRNA Nuclease Resistance via Nucleobase-Mimicking Small Molecule Self-Assembly Description: Nucleic acid therapeutics offer high efficacy and specificity but suffer from instability, requiring ultra-low storage temperatures and degrading rapidly in ...
New Approaches for Functional Oligonucleotides: RNA Activation and Non-Nucleosidic Aptamers.
Date: November 20, 2025 Time: 11-12pm EST / 5-6pm CET Title: New Approaches for Functional Oligonucleotides: RNA Activation and Non-Nucleosidic Aptamers Description: This talk will highlight two complementary approaches aimed at expanding the functional scope of oligonucleotide therapeutics. First, I will ...
DNA-based tools for the study and treatment of Parkinson’s Disease
Date: November 6, 2025 Time: 11-12pm EST / 5-6pm CET Title: DNA-based tools for the study and treatment of Parkinson’s Disease Description: Aptamers are short stretches of DNA that fold into 3-dimensional shapes that can act as pockets for binding other ...
OTS Member Highlight – Dr. Richard Geary
Dr. Richard Geary, current OTS President, has always been passionate about health and finding ways to improve people's well-being. Born with a rare disease, he was in the medical spotlight at a young age; now, he’s known for his incredible contributions to the scientific ...
Binding and Ligand Activation Driven Enrichment–Directed Evolution of SaCas9 gRNAs Improves Gene Editing Efficiency
Authors: Telmo Llanga, Korie Bush, Ying Sun, Amy Yan, Jonathan Zhou, Jan Gorodkin, and Bruce A. Sullenger AbstractClustered regularly interspaced short palindromic repeats-based editing is inefficient at over two-thirds of genetic targets. A primary cause is ribonucleic acid (RNA) misfolding that can occur between the ...
