2020 Dr. Alan M. Gewirtz Memorial Scholarship Award Winner Chantal M. Ferguson
Chantal M. Ferguson, RNA Therapeutics Institute, University of Massachusetts Medical School RNAi modulation of APOE as a potential therapeutic for Alzheimer Disease Biography: Chantal joined the Khvorova Lab in 2017 with an interest in developing new tools to understand and treat neurological disorders. Her ...
July 2020 Joint Papers of the Month
Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults. Mulligan MJ, Lyke KE, Kitchin N, Absalon J, Gurtman A, Lockhart S, Neuzil K, Raabe V, Bailey R, Swanson KA, Li P, Koury K, Kalina W, Cooper D, Fontes-Garfias C, Shi PY, Türeci Ö, ...
Directed RNase H cleavage of nascent transcripts causes transcription termination
Lai F, Damle SS, Ling KK, Rigo F Read More
Inclisiran for the treatment of heterozygous familial hyper-cholesterolemia (Raal et al., 2020)
Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP; ORION-9 Investigators. Lee JS, Mendell JT. Read More
Base editors for simultaneous introduction of C-to-T and A-to-G mutations.
Sakata RC, Ishiguro S, Mori H, Tanaka M, Tatsuno K, Ueda H, Yamamoto S, Seki M, Masuyama N, Nishida K, Nishimasu H, Arakawa K, Kondo A, Nureki O, Tomita M, Aburatani H, Yachie N. Nat Biotechnol. 2020 Jul;38(7):865-869. Pubmed
Combinatorial Inhibition of Cell Surface Receptors Using Dual Aptamer-Functionalized Nanoconstructs for Cancer Treatment.
Lee H, Kim TH, Park D, Jang M, Chung JJ, Kim SH, Kim SH, Lee KH, Jung Y, Oh SJ. Pharmaceutics. 2020 Jul 21;12(7):E689. Pubmed
Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors.
Anzalone AV, Koblan LW, Liu DR. Nat Biotechnol. 2020 Jul;38(7):824-844. Pubmed
Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures.
Kappel K, Zhang K, Su Z, Watkins AM, Kladwang W, Li S, Pintilie G, Topkar VV, Rangan R, Zheludev IN, Yesselman JD, Chiu W, Das R. Nat Methods. 2020 Jul;17(7):699-707. Pubmed
Cell-free biosensors for rapid detection of water contaminants.
Jung JK, Alam KK, Verosloff MS, Capdevila DA, Desmau M, Clauer PR, Lee JW, Nguyen PQ, Pastén PA, Matiasek SJ, Gaillard JF, Giedroc DP, Collins JJ, Lucks JB. Nat Biotechnol. 2020 Jul 6. Pubmed
Functional annotation of human long noncoding RNAs via molecular phenotyping.
Ramilowski JA, Yip CW, Agrawal S, Chang JC, Ciani Y, Kulakovskiy IV, Mendez M, Ooi JLC, Ouyang JF, Parkinson N, Petri A, Roos L, Severin J, Yasuzawa K, Abugessaisa I, Akalin A, Antonov IV, Arner E, Bonetti A, Bono H, Borsari B, Brombacher F, Cameron ...
