High-throughput identification of synthetic riboswitches by barcode-free amplicon-sequencing in human cells
Strobel B, Spöring M, Klein H, Blazevic D, Rust W, Sayols S, Hartig JS, Kreuz S. Nat Commun. 2020 Feb 5;11(1):714. PubMed
Impact of Phosphorothioate Chirality on Double-Stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs
Sakamuri S, Eltepu L, Liu D, Lam S, Meade BR, Liu B, Dello Iacono G, Kabakibi A, Luukkonen L, Leedom T, Foster M, Bradshaw CW. Chembiochem. 2019 Dec 21. PubMed
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
Patel S, Ashwanikumar N, Robinson E, Xia Y, Mihai C, Griffith JP 3rd, Hou S, Esposito AA, Ketova T, Welsher K, Joyal JL, Almarsson Ö, Sahay G. Nat Commun. 2020 Feb 20;11(1):983. PubMed
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier
Marcos-Contreras OA, Greineder CF, Kiseleva RY, Parhiz H, Walsh LR, Zuluaga-Ramirez V, Myerson JW, Hood ED, Villa CH, Tombacz I, Pardi N, Seliga A, Mui BL, Tam YK, Glassman PM, Shuvaev VV, Nong J, Brenner JS, Khoshnejad M, Madden T, Weissmann D, Persidsky Y, Muzykantov ...
Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses
Leong WI, Ames RY, Haverkamp JM, Torres L, Kline J, Bans A, Rocha L, Gallotta M, Guiducci C, Coffman RL, Janatpour MJ. Oncotarget. 2019 Dec 31;10(68):7220-7237. PubMed
Regulation of gene expression by cis-acting long non-coding RNAs
Gil N, Ulitsky I. Nat Rev Genet. 2020 Feb;21(2):102-117. PubMed
January 2020 Joint Papers of the Month
Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination Lai F, Damle SS, Ling KK, Rigo F. Mol Cell. 2020 Jan 3. pii: S1097-2765(19)30959-1. Joint First Authors Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination. Lee JS, Mendell JT. Mol ...
The Dynamics of Cytoplasmic mRNA Metabolism.
Eisen TJ, Eichhorn SW, Subtelny AO, Lin KS, McGeary SE, Gupta S, Bartel DP. Mol Cell. 2019 Dec 30. pii: S1097-2765(19)30896-2. PubMed
Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid (siRNA), Givosiran, in Patients with Acute Hepatic Porphyria.
Agarwal S, Simon AR, Goel V, Habtemariam BA, Clausen VA, Kim JB, Robbie GJ. Clin Pharmacol Ther. 2020 Jan 29. PubMed
Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.
Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, Tardif JC, Baum SJ, Steinhagen-Thiessen E, Shapiro MD, Stroes ES, Moriarty PM, Nordestgaard BG, Xia S, Guerriero J, Viney NJ, O'Dea L, Witztum JL; AKCEA-APO(a)-LRx Study Investigators. N Engl J Med. 2020 Jan 1. PubMed
