Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier
Marcos-Contreras OA, Greineder CF, Kiseleva RY, Parhiz H, Walsh LR, Zuluaga-Ramirez V, Myerson JW, Hood ED, Villa CH, Tombacz I, Pardi N, Seliga A, Mui BL, Tam YK, Glassman PM, Shuvaev VV, Nong J, Brenner JS, Khoshnejad M, Madden T, Weissmann D, Persidsky Y, Muzykantov ...
Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses
Leong WI, Ames RY, Haverkamp JM, Torres L, Kline J, Bans A, Rocha L, Gallotta M, Guiducci C, Coffman RL, Janatpour MJ. Oncotarget. 2019 Dec 31;10(68):7220-7237. PubMed
Regulation of gene expression by cis-acting long non-coding RNAs
Gil N, Ulitsky I. Nat Rev Genet. 2020 Feb;21(2):102-117. PubMed
January 2020 Joint Papers of the Month
Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination Lai F, Damle SS, Ling KK, Rigo F. Mol Cell. 2020 Jan 3. pii: S1097-2765(19)30959-1. Joint First Authors Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination. Lee JS, Mendell JT. Mol ...
The Dynamics of Cytoplasmic mRNA Metabolism.
Eisen TJ, Eichhorn SW, Subtelny AO, Lin KS, McGeary SE, Gupta S, Bartel DP. Mol Cell. 2019 Dec 30. pii: S1097-2765(19)30896-2. PubMed
Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid (siRNA), Givosiran, in Patients with Acute Hepatic Porphyria.
Agarwal S, Simon AR, Goel V, Habtemariam BA, Clausen VA, Kim JB, Robbie GJ. Clin Pharmacol Ther. 2020 Jan 29. PubMed
Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.
Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, Tardif JC, Baum SJ, Steinhagen-Thiessen E, Shapiro MD, Stroes ES, Moriarty PM, Nordestgaard BG, Xia S, Guerriero J, Viney NJ, O'Dea L, Witztum JL; AKCEA-APO(a)-LRx Study Investigators. N Engl J Med. 2020 Jan 1. PubMed
Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis.
Sutherland JE, Hettinger JL, Chan A, Gilbert J, Warner GL, Davis WP. Nucleic Acid Ther. 2019 Dec 10. PubMed
Antibody Opsonization of a TLR9 Agonist-Containing Virus-like Particle Enhances In Situ Immunization.
Lemke-Miltner CD, Blackwell SE, Yin C, Krug AE, Morris AJ, Krieg AM, Weiner GJ. J Immunol. 2020 Jan 17. pii: ji1900742. PubMed
Sequence Multiplicity within Spherical Nucleic Acids.
Huang ZN, Cole LE, Callmann CE, Wang S, Mirkin CA. ACS Nano. 2020 Jan 28;14(1):1084-1092. PubMed
