January 2020 Joint Papers of the Month
Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination Lai F, Damle SS, Ling KK, Rigo F. Mol Cell. 2020 Jan 3. pii: S1097-2765(19)30959-1. Joint First Authors Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination. Lee JS, Mendell JT. Mol ...
The Dynamics of Cytoplasmic mRNA Metabolism.
Eisen TJ, Eichhorn SW, Subtelny AO, Lin KS, McGeary SE, Gupta S, Bartel DP. Mol Cell. 2019 Dec 30. pii: S1097-2765(19)30896-2. PubMed
Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid (siRNA), Givosiran, in Patients with Acute Hepatic Porphyria.
Agarwal S, Simon AR, Goel V, Habtemariam BA, Clausen VA, Kim JB, Robbie GJ. Clin Pharmacol Ther. 2020 Jan 29. PubMed
Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.
Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, Tardif JC, Baum SJ, Steinhagen-Thiessen E, Shapiro MD, Stroes ES, Moriarty PM, Nordestgaard BG, Xia S, Guerriero J, Viney NJ, O'Dea L, Witztum JL; AKCEA-APO(a)-LRx Study Investigators. N Engl J Med. 2020 Jan 1. PubMed
Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis.
Sutherland JE, Hettinger JL, Chan A, Gilbert J, Warner GL, Davis WP. Nucleic Acid Ther. 2019 Dec 10. PubMed
Antibody Opsonization of a TLR9 Agonist-Containing Virus-like Particle Enhances In Situ Immunization.
Lemke-Miltner CD, Blackwell SE, Yin C, Krug AE, Morris AJ, Krieg AM, Weiner GJ. J Immunol. 2020 Jan 17. pii: ji1900742. PubMed
Sequence Multiplicity within Spherical Nucleic Acids.
Huang ZN, Cole LE, Callmann CE, Wang S, Mirkin CA. ACS Nano. 2020 Jan 28;14(1):1084-1092. PubMed
Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Installed Polymeric Nanocarrier.
Min HS, Kim HJ, Naito M, Ogura S, Toh K, Hayashi K, Kim BS, Fukushima S, Anraku Y, Miyata K, Kataoka K. Angew Chem Int Ed Engl. 2020 Jan 29. PubMed
Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.
Yang Z, Shi J, Xie J, Wang Y, Sun J, Liu T, Zhao Y, Zhao X, Wang X, Ma Y, Malkoc V, Chiang C, Deng W, Chen Y, Fu Y, Kwak KJ, Fan Y, Kang C, Yin C, Rhee J, Bertani P, Otero J, Lu ...
Selection of Aptamers with Large Hydrophobic 2′-Substituents.
Shao Q, Chen T, Sheng K, Liu Z, Zhang Z, Romesberg FE. J Am Chem Soc. 2020 Jan 21. PubMed
