2018 OTS Lifetime Achievement Award Winner Marvin H. Caruthers
Marvin H. Caruthers Distinguished Professor of Chemistry University of Colorado Boulder, Colorado Marvin H. Caruthers is a Distinguished Professor of Biochemistry and Chemistry at the University of Colorado, Boulder. A Guggenheim Fellow, Dr. Caruthers received his B.S. in Chemistry from Iowa State University, his Ph.D. ...
Interview with Pad Chivukula, PhD
My mentor helped me to see the potential of pharmaceutical research on our society.
2018 OTS Poster Award Winners
001 Bruno Godinho, University of Massachusetts Medical School Neuroactive siRNA Scaffold Enables Broad Distribution and Robust Gene Silencing Throughout the Central Nervous System: Preclinical Studies in Large Mammals 002 Julia Alterman, University of Massachusetts Medical School Potent and long-term RNA interference-based silencing of huntingtin expression ...
Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease
Baker SK, Chen ZL, Norris EH, Revenko AS, MacLeod AR, Strickland S. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9687-E9696. PubMed
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
Southwell AL, Kordasiewicz HB, Langbehn D, Skotte NH, Parsons MP, Villanueva EB, Caron NS, Østergaard ME, Anderson LM, Xie Y, Cengio LD, Findlay-Black H, Doty CN, Fitsimmons B, Swayze EE, Seth PP, Raymond LA, Frank Bennett C, Hayden MR. Sci Transl Med. 2018 Oct 3;10(461). ...
Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7
Niu C, Prakash TP, Kim A, Quach JL, Huryn LA, Yang Y, Lopez E, Jazayeri A, Hung G, Sopher BL, Brooks BP, Swayze EE, Bennett CF, La Spada AR. Sci Transl Med. 2018 Oct 31;10(465). PubMed
Loss of hepatocyte β-Catenin protects mice from experimental porphyria-associated liver injury
Saggi H, Maitra D, Jiang A, Zhang R, Wang P, Cornuet P, Singh S, Locker J, Ma X, Dailey H, Abrams M, Omary MB, Monga SP, Nejak-Bowen K. J Hepatol. 2018 Oct 1. pii: S0168-8278(18)32442-5. PubMed
Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy
Buono S, Ross JA, Tasfaout H, Levy Y, Kretz C, Tayefeh L, Matson J, Guo S, Kessler P, Monia BP, Bitoun M, Ochala J, Laporte J, Cowling BS. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11066-11071. PubMed
LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis
Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z. Nat Cell Biol. ...
The cisplatin-induced lncRNA PANDAR dictates the chemoresistance of ovarian cancer via regulating SFRS2-mediated p53 phosphorylation
Wang H, Fang L, Jiang J, Kuang Y, Wang B, Shang X, Han P, Li Y, Liu M, Zhang Z, Li P. Cell Death Dis. 2018 Oct 30;9(11):1103. PubMed
