Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis
Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S. JCI Insight. 2019 Oct 15. PubMed ...
Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart
Li H, Fan J, Zhao Y, Zhang X, Dai B, Zhan J, Yin Z, Nie X, Fu XD, Chen C, Wang DW. Circ Res. 2019 Oct 22. PubMed
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease
Kim J, Hu C, Moufawad El Achkar C, Black LE, Douville J, Larson A, Pendergast MK, Goldkind SF, Lee EA, Kuniholm A, Soucy A, Vaze J, Belur NR, Fredriksen K, Stojkovska I, Tsytsykova A, Armant M, DiDonato RL, Choi J, Cornelissen L, Pereira LM, Augustine ...
Spliceosomal disruption of the non-canonical BAF complex in cancer
Inoue D, Chew GL, Liu B, Michel BC, Pangallo J, D'Avino AR, Hitchman T, North K, Lee SC, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK. Nature. ...
Search-and-replace genome editing without double-strand breaks or donor DNA
Anzalone AV, Randolph PB, Davis JR, Sousa AA, Koblan LW, Levy JM, Chen PJ, Wilson C, Newby GA, Raguram A, Liu DR. Nature. 2019 Oct 21. PubMed
Hypoxia-activated PEGylated aptamer/antibody for cancer imaging with improved specificity
Zhou F, Fu T, Huang Q, Kuai H, Mo L, Liu H, Wang Q, Peng Y, Han D, Zhao Z, Fang X, Tan W. J Am Chem Soc. 2019 Oct 4. PubMed
Endocytic Pathways and Intracellular Transport of Aptamer-Drug Conjugates in Live Cells Monitored by Single-Particle Tracking
Lv C, Yang C, Ding D, Sun Y, Wang R, Han D, Tan W. Anal Chem. 2019 Oct 24. PubMed
The role of apolipoprotein- and vitronectin-enriched protein corona on lipid nanoparticles for in vivo targeted delivery and transfection of oligonucleotides in murine tumor models
Chen D, Parayath N, Ganesh S, Wang W, Amiji M. Nanoscale. 2019 Oct 28;11(40):18806-18824. PubMed
Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing
Brown JM, Dahlman JE, Neuman KK, Prata CAH, Krampert MC, Hadwiger PM, Vornlocher HP. Nucleic Acid Ther. 2019 Oct;29(5):231-244. PubMed
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide
Wu LP, Ahmadvand D, Su J, Hall A, Tan X, Farhangrazi ZS, Moghimi SM. Nat Commun. 2019 Oct 11;10(1):4635. PubMed
