TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
Schleimann MH, Kobberø ML, Vibholm LK, Kjær K, Giron LB, Busman-Sahay K, Chan CN, Nekorchuk M, Schmidt M, Wittig B, Damsgaard TE, Ahlburg P, Hellfritzsch MB, Zuwala K, Rothemejer FH, Olesen R, Schommers P, Klein F, Dweep H, Kossenkov A, Nyengaard JR, Estes JD, Abdel-Mohsen ...
In Vitro Drug-Drug Interaction Evaluation of GalNAc conjugated siRNAs Against CYP450 Enzymes and Transporters
Ramsden D, Wu JT, Zerler B, Iqbal S, Jiang J, Clausen V, Aluri K, Gu Y, Dennin S, Kim J, Chong S. Drug Metab Dispos. 2019 Jul 3. PubMed
Metabolism and Disposition of Volanesorsen, a 2′ MOE Antisense Oligonucleotide, Across Species
Post N, Yu R, Greenlee S, Gaus H, Hurh E, Matson J, Wang Y. Drug Metab Dispos. 2019 Jul 26. PubMed
Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure-Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin-Mediated (hATTR) Amyloidosis
Zhang X, Goel V, Attarwala H, Sweetser MT, Clausen VA, Robbie GJ. J Clin Pharmacol. 2019 Jul 19. PubMed
Human 5′ UTR design and variant effect prediction from a massively parallel translation assay
Sample PJ, Wang B, Reid DW, Presnyak V, McFadyen IJ, Morris DR, Seelig G. Nat Biotechnol. 2019 Jul;37(7):803-809. PubMed
mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency
Cao J, An D, Galduroz M, Zhuo J, Liang S, Eybye M, Frassetto A, Kuroda E, Funahashi A, Santana J, Mihai C, Benenato KE, Kumarasinghe ES, Sabnis S, Salerno T, Coughlan K, Miracco EJ, Levy B, Besin G, Schultz J, Lukacs C, Guey L, Finn ...
Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling
Garcia-Campos MA, Edelheit S, Toth U, Safra M, Shachar R, Viukov S, Winkler R, Nir R, Lasman L, Brandis A, Hanna JH, Rossmanith W, Schwartz S. Cell. 2019 Jul 25;178(3):731-747.e16. PubMed
Developmental dynamics of lncRNAs across mammalian organs and species
Sarropoulos I, Marin R, Cardoso-Moreira M, Kaessmann H. Nature. 2019 Jul;571(7766):510-514. PubMed
Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters
Park MS, Araya-Secchi R, Brackbill JA, Phan HD, Kehling AC, Abd El-Wahab EW, Dayeh DM, Sotomayor M, Nakanishi K. Mol Cell. 2019 Jun 27. pii: S1097-2765(19)30444-7. PubMed
Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2
Sheu-Gruttadauria J, Xiao Y, Gebert LF, MacRae IJ. EMBO J. 2019 Jul 1;38(13):e101153. PubMed
