Inclisiran’s Interesting Path to Treating LDL Cholesterol
When The Medicines Company licensed inclisiran, they envisioned a drug for the masses that would save the healthcare system money and be reasonably priced for patients. Despite the company having little experience in the oligonucleotide therapeutics field, it went all in on the drug, selling ...
Alnylam’s 20-Year Journey of Discovery
Twenty years ago, a group of scientists intent on developing a new class of medicine using RNAi technology came together and formed Alnylam Pharmaceuticals, a name symbolizing their passion for discovery. The bright center star of Orion's belt, Alnilam, has long been used as a ...
Trainee Spotlight Series: Remko Goossens & Priyanka Shukla
Time: 8AM Pacific | 11AM Eastern | 5PM CET Date: May 18, 2023 Speakers: Remko Goossens Leiden University Medical Center Remko will outline our findings concerning the relationship between the splicing speed of ...
Realizing the Promise of CRISPR Therapeutics: In Vivo and Cell Therapy Applications
Time: 8am Pacific | 11am Eastern | 5pm CET Date: May 11, 2023 Laura will be discussing preclinical and clinical data for CRISPR based investigational drug candidates from Intellia Therapeutics. Speakers: Laura Sepp-Lorenzino, ...
The World of GalNAc-Conjugates in Nucleic Acid Therapeutics
Time: 5pm Amsterdam - 9 AM MST Date: April 27, 2023 Speakers: Mano Manoharan, PhD View Bio
Trainee Spotlight Series: Jeremy Hall and Tracy Mallette
Time: 5pm Amsterdam Date: April 13, 2023 Topics/Speakers: Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3 Jeremy Hall City of Hope & Keck Graduate Institute Jeremy will present a summary of the ...
Trainee Spotlight Series: OTS 2022 poster winners
Time: 05:00 PM - Amsterdam, Berlin, Rome, Stockholm, Vienna Date: March 30, 2023 Topics/Speakers: Therapeutic application of engineered U1 snRNAs in retinopathies and other disorders Paolo Pigini Assessing efficacy ...
Spotting Stubborn Indirect Effects in Oligonucleotide Therapeutics
Time: 4pm CET Date: March 16, 2023 We use chemistry to improve the properties of nucleic acid therapeutics including antisense oligonucleotides, siRNAs, and genome editing approaches. I will walk through a recent study we carried out trying to activate frataxin expression to treat ...
New CRISPR Technique May Be the Solution to Replacing Entire Genes
Ever since it was discovered that CRISPR could be used for genome editing, scientists across the world have been working on creating safe, effective ways to use this incredible tool to cure many different human diseases. From the first CRISPR-Cas system that works as ...
Towards Developing Greener Methods for Oligonucleotide Synthesis
Time: 5pm Amsterdam - 9 AM MST Date: February 23, 2023 Research: My research focuses on the development of novel methodologies for oligonucleotide synthesis, with a particular emphasis on reducing the solvent footprint of oligonucleotide synthesis. Webinar topic: My webinar will largely focus on ...
