Trainee Spotlight Series: Jeremy Hall and Tracy Mallette
Time: 5pm Amsterdam Date: April 13, 2023 Topics/Speakers: Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3 Jeremy Hall City of Hope & Keck Graduate Institute Jeremy will present a summary of the ...
Trainee Spotlight Series: OTS 2022 poster winners
Time: 05:00 PM - Amsterdam, Berlin, Rome, Stockholm, Vienna Date: March 30, 2023 Topics/Speakers: Therapeutic application of engineered U1 snRNAs in retinopathies and other disorders Paolo Pigini Assessing efficacy ...
Spotting Stubborn Indirect Effects in Oligonucleotide Therapeutics
Time: 4pm CET Date: March 16, 2023 We use chemistry to improve the properties of nucleic acid therapeutics including antisense oligonucleotides, siRNAs, and genome editing approaches. I will walk through a recent study we carried out trying to activate frataxin expression to treat ...
New CRISPR Technique May Be the Solution to Replacing Entire Genes
Ever since it was discovered that CRISPR could be used for genome editing, scientists across the world have been working on creating safe, effective ways to use this incredible tool to cure many different human diseases. From the first CRISPR-Cas system that works as ...
Towards Developing Greener Methods for Oligonucleotide Synthesis
Time: 5pm Amsterdam - 9 AM MST Date: February 23, 2023 Research: My research focuses on the development of novel methodologies for oligonucleotide synthesis, with a particular emphasis on reducing the solvent footprint of oligonucleotide synthesis. Webinar topic: My webinar will largely focus on ...
Trainee Spotlight Series: OTS 2023 Junior Board Members
Time: 5pm Amsterdam - 9 AM MST Date: February 9, 2023 Speakers: Krystal Johnson, MSc Investigating the consequences of nuclear AGO2 in colon cancer model systems View Bio Description Argonaute proteins ...
They Created a Drug for Susannah. What About Millions of Other Patients?
By Erika Check Hayden (New York Times) Photographs by Brittainy Newman Scientists have made rapid progress in customizing drugs for ultrarare diseases. The hard part now is making such treatments on a large scale. Susannah Rosen, 8, spent much of her childhood in hospitals ...
Using CRISPR to Personalize Cancer Immunotherapy Treatment
In 2020, there were an estimated 18.1 million cases of cancer worldwide (excluding non-melanoma skin cancer). Breast, lung, and colorectal cancer were the most common and together contributed to 35.4% of these cases. In the same year, 9.5 million cancer-related deaths were reported. According to ...
Trainee Spotlight Series: OTS 2022 Poster Winners
Time: 5pm Amsterdam - 9 AM MST Date: January 26th, 2023 Topic / Speakers: Quantitative measurement of cytosolic and nuclear penetration of oligonucleotide therapeutics and investigation of sequence-penetration relationships Nefeli Batistatou, MSc Nefeli Batistatou, ...
2022 OTS Poster Award Winners
P004 Allien Balian Nucleic acid probes as biorecognition molecules for cancer detection P019 Chisato Terada BROTHERSTM platform: overcoming toxicity using a novel antisense architecture P030 Dhrubajyoti Datta PhD Evaluation of the Role of Epigenetic Modifications in siRNAs with 2′-Modified, N6-Alkyl Adenosine Nucleotides: Maintaining RNAi Potency ...
