A mouse tissue atlas of small noncoding RNA.
Isakova A, Fehlmann T, Keller A, Quake SR. Proc Natl Acad Sci U S A. 2020 Sep 25:202002277. Pubmed
Knockdown of liver-derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function
Liu J, Cooley BC, Akinc A, Butler J, Borodovsky A. Thromb Res. 2020 Aug 28;196:200-205. Pubmed
2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA
Davis SM, Sousa J, Vangjeli L, Hassler MR, Echeverria D, Knox E, Turanov AA, Alterman JF, Khvorova A. Mol Ther Nucleic Acids. 2020 Sep 4;21:266-277. Pubmed
Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference
Ferguson CM, Echeverria D, Hassler M, Ly S, Khvorova A. Mol Ther Nucleic Acids. 2020 Sep 4;21:384-393. Pubmed
Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity
Liang XH, Nichols JG, De Hoyos CL, Crooke ST. Nucleic Acids Res. 2020 Sep 25;48(17):9840-9858 Pubmed
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy
Cook CN, Wu Y, Odeh HM, Gendron TF, Jansen-West K, Del Rosso G, Yue M, Jiang P, Gomes E, Tong J, Daughrity LM, Avendano NM, Castanedes-Casey M, Shao W, Oskarsson B, Tomassy GS, McCampbell A, Rigo F, Dickson DW, Shorter J, Zhang YJ, Petrucelli L. ...
August 2020 Joint Papers of the Month
Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression Lim KH, Han Z, Jeon HY, Kach J, Jing E, Weyn-Vanhentenryck S, Downs M, Corrionero A, Oh R, Scharner J, Venkatesh A, Ji S, Liau G, Ticho B, Nash H, Aznarez I. Nat Commun. ...
Interview with Aurélie Goyenvalle, PhD
Aurélie Goyenvalle, PhD University of Versailles Group Leader Biotherapy for Neuromuscular Diseases U1179 UVSQ-INSERM How did you become interested in the field of oligonucleotides? I started my PhD in 2002 in Genethon in France working on therapeutics for muscular dystrophies, and it was the ...
OTS 2020 List of Poster Winners
13 O6-Alkylguanine DNA Alkyltransferase Mediated Disassembly of a DNA Tetrahedron William Copp, PhD Candidate, Concordia University 31 Vitamin Lipid Nanoparticles Enable Adoptive Macrophage Transfer for the Treatment of Multidrug-Resistant Bacterial Sepsis Xucheng Hou, Graduate Student, The Ohio State University 35 The Global Effects of TNRC6 ...
2021 OTS Lifetime Achievement Award Winner C. Frank Bennett, PhD
Frank Bennett, Ph.D. Ionis Pharmaceuticals Dr. Bennett is the executive vice president and chief scientific officer at Ionis Pharmaceuticals and one of the founding members of the company. He is responsible for continuing to advance antisense technology and expanding Ionis drug discovery platform. Dr. ...
