2021 OTS Lifetime Achievement Award Winner C. Frank Bennett, PhD
Frank Bennett, Ph.D. Ionis Pharmaceuticals Dr. Bennett is the executive vice president and chief scientific officer at Ionis Pharmaceuticals and one of the founding members of the company. He is responsible for continuing to advance antisense technology and expanding Ionis drug discovery platform. Dr. ...
2020 OTS Lifetime Achievement Award Winner Ryszard Kole, PhD
Ryszard Kole, PhD University of North Carolina, Chapel Hill Dr. Kole received his Ph.D. degree from the Institute of Biochemistry and Biophysics, Polish Academy of Sciences, in Warsaw, where he studied the role of ribonucleases on cell function. In 1977 he moved to USA ...
Antisense Drug Discovery and Development Technology Considered in a Pharmacological Context
Crooke ST, Liang XH, Crooke RM, Baker BF, Geary RS. Biochem Pharmacol. 2020 Aug 12:114196. Pubmed
Maximizing transcription of nucleic acids with efficient T7 promoters
Conrad T, Plumbom I, Alcobendas M, Vidal R, Sauer S. Commun Biol. 2020 Aug 14;3(1):439. Pubmed
Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment
Hewitt SL, Bailey D, Zielinski J, Apte A, Musenge F, Karp R, Burke S, Garcon F, Mishra A, Gurumurthy S, Watkins A, Arnold K, Moynihan J, Clancy-Thompson E, Mulgrew K, Adjei G, Deschler K, Potz D, Moody G, Leinster DA, Novick S, Sulikowski M, Bagnall ...
Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults.
Mulligan MJ, Lyke KE, Kitchin N, Absalon J, Gurtman A, Lockhart S, Neuzil K, Raabe V, Bailey R, Swanson KA, Li P, Koury K, Kalina W, Cooper D, Fontes-Garfias C, Shi PY, Türeci Ö, Tompkins KR, Walsh EE, Frenck R, Falsey AR, Dormitzer PR, Gruber ...
Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia
Gaudet D, Karwatowska-Prokopczuk E, Baum SJ, Hurh E, Kingsbury J, Bartlett VJ, Figueroa AL, Piscitelli P, Singleton W, Witztum JL, Geary RS, Tsimikas S, St L O'Dea L. Eur Heart J. 2020 Aug 29:ehaa689. Pubmed
Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system.
Sullivan JM, Mazur C, Wolf DA, Horky L, Currier N, Fitzsimmons B, Hesterman J, Pauplis R, Haller S, Powers B, Tayefeh L, DeBrosse-Serra B, Hoppin J, Kordasiewicz H, Swayze EE, Verma A. J Transl Med. 2020 Aug 8;18(1):309. Pubmed
The dose threshold for nanoparticle tumour delivery
Ouyang B, Poon W, Zhang YN, Lin ZP, Kingston BR, Tavares AJ, Zhang Y, Chen J, Valic MS, Syed AM, MacMillan P, Couture-Senécal J, Zheng G, Chan WCW. Nat Mater. 2020 Aug 10. Pubmed
Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras
Langner HK, Jastrzebska K, Caruthers MH. J Am Chem Soc. 2020 Aug 31. Pubmed
