2019 OTS Lifetime Achievement Award Winner Muthiah (Mano) Manoharan
Muthiah (Mano) Manoharan, Ph.D Alnylam Pharmaceuticals Muthiah (Mano) Manoharan serves as a Senior Vice President, a Scientific Advisory Board Member, and a Distinguished Research Scientist at Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA. In 2003, he was the first chemist hired at Alnylam. He and his ...
Congratulations to our 2019 Award Winners!
Dr. Alan M. Gewirtz Memorial Scholarship Award: Bruno M.D.C. Godinho, PhD, RNA Therapeutics Institute, UMass Medical School
Patient Representative Webinar
Presenter: Daniel O’Reilly and Joseph Ochaba (Oligonucleotide Therapeutics Society) Date: November 19, 2019 Description: With a constantly growing list of oligonucleotide therapies that are entering the clinics, these exciting research molecules-turned-therapeutic strategy are starting to lead the way in treatments for many devastating diseases. ...
Dual Mechanisms of Action of Self-Delivering, Anti-HIV-1 FANA Oligonucleotides as a Potential New Approach to HIV Therapy
Takahashi M, Li H, Zhou J, Chomchan P, Aishwarya V, Damha MJ, Rossi JJ. Mol Ther Nucleic Acids. 2019 Sep 6; 17: 615–625 PubMed
Targeting castration-resistant prostate cancer with androgen receptor antisense oligonucleotide therapy
De Velasco MA, Kura Y, Sakai K, Hatanaka Y, Davies BR, Campbell H, Klein S, Kim Y, MacLeod AR, Sugimoto K, Yoshikawa K, Nishio K, Uemura H. JCI Insight. 2019 Sep 5;4(17). PubMed
Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1
Vickers TA, Rahdar M, Prakash TP, Crooke ST. Nucleic Acids Res. 2019 Sep 9. PubMed
Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor
Liu Y, Kanda A, Wu D, Ishizuka ET, Kase S, Noda K, Ichihara A, Ishida S. Mol Ther Nucleic Acids. 2019 Sep 6;17:113-125. PubMed
Targeted Delivery of C/EBPα-saRNA by RNA Aptamers Shows Anti-tumor Effects in a Mouse Model of Advanced PDAC
Yoon S, Huang KW, Andrikakou P, Vasconcelos D, Swiderski P, Reebye V, Sodergren M, Habib N, Rossi JJ. Mol Ther Nucleic Acids. 2019 Aug 22;18:142-154. PubMed
MicroRNA-221 Is Cardioprotective and Anti-fibrotic in a Rat Model of Myocardial Infarction
Zhou Y, Richards AM, Wang P. Mol Ther Nucleic Acids. 2019 Sep 6;17:185-197. PubMed
Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
Lee EC, Valencia T, Allerson C, Schairer A, Flaten A, Yheskel M, Kersjes K, Li J, Gatto S, Takhar M, Lockton S, Pavlicek A, Kim M, Chu T, Soriano R, Davis S, Androsavich JR, Sarwary S, Owen T, Kaplan J, Liu K, Jang G, Neben ...
