OTS President’s Pick Paper – July 2022
By: David Corey Establishing an environment in which rigorous scientific inquiry is practiced: A personal journey. Stanley Crooke Nucleic Acids Research, gkac526, https://doi.org/10.1093/nar/gkac526 Published: 08 July 2022. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac526/6633881?login=true The Story of Ionis Pharmaceuticals For those new to the field, Ionis Pharmaceuticals has always been ...
A New Conjugated siRNA provides broad delivery in the CNS, Lung, and Eye
Ever since the groundbreaking discovery of RNA interference and its role as a gene-silencing mechanism in mammalian cells, an ongoing process of discovery has been underway to harness its potential in treating disease. A key mechanism that induces gene-silencing in the RNA pathway is ...
Transitioning from Trainee to Faculty – A conversation with Prof. Bethany Powell Gray
Time: 11am - 12pm EST Date: July 14, 2022 Description: Join us for an open discussion with Dr. Bethany Powell Gray, who is an Assisstant Professor at the John Hopkins University School of Medicine, where we will talk about the postdoc to faculty ...
Positive Results from Tofersen VALOR Trial and OLE Integrated Data
People diagnosed with the progressive neurodegenerative disease ALS previously had no hope of an effective treatment that could delay the onset of symptoms or extend their lifespan. However, as a result of recent advances in science and medicine, multiple oligonucleotide therapeutics are being developed ...
Trainee Spotlight Series: Yan Li and Roberto El Khoury
Title: Trainee Spotlight Series: Yan Li and Roberto El Khoury Time: 11am EST Date: July 7, 2022 Description: This Trainee Spotlight features Yan Li, a Ph.D. student at the University of California, Los Angeles, and Roberto El Khoury a Ph.D. candidate at McGill ...
OTS President’s Paper Pick – June 2022
Successful nucleic acid therapeutic projects have one thing in common - rigor. Lack of controls has many consequences ranging from failed companies, seminars that waste the time of all involved, and lost hopes of patients. In this “President’s Pick”, Past President Annemieke Aartsma-Rus lays ...
CRISPR Babies and the Scientist Behind Their Editing
At an international genome-editing summit in Hong Kong, MIT Technology Review reporter Antonio Regalado uncovered the existence of the CRISPR baby project. The now infamous scientist, He Jiankui, had used CRISPR-Cas9, a genetic engineering tool, to edit the CCR5 gene of three embryos with ...
Interview with M.Sc. Philipp Niklas Ostermann, PhD Student
M.Sc. Philipp Niklas Ostermann PhD Student Heiner Schaal Lab Institute of Virology University Hospital Düsseldorf How did you become interested in the field of oligonucleotides? I first encountered the use of antisense oligonucleotides as potential therapeutics during my master’s thesis, which was about inhibition of ...
CRISPR Patent Rights and Their Effect on the Industry
A decade ago, Jennifer Doudna of the University of California, Berkley and Emmanuelle Charpentier of the Max Planck Institute for Infection Biology drafted blueprints for a groundbreaking gene editing technique. The two scientists had found a way to cut and make precise changes to ...
Pitfalls and Progress in the Development of Immune Stimulatory Nucleic Acids
Date: June 2, 2022 Time: 11-12 EST Speaker: Art Krieg, MD, Checkmate Pharmaceuticals Description: Art Krieg, MD, CSO at Checkmate Pharmaceuticals, focuses his research on stimulating innate immunity with immune stimulatory DNA and RNA. Join us as Dr. Krieg discusses the history of efforts ...
