Oligonucleotides and the OTS Community Provide Excellent Solutions to the COVID-19 Pandemic
Oligonucleotide therapies are relatively new in the field of medicine, but they have allowed us to make astounding progress in the fight against COVID-19. Rather than simply repurposing existing drugs or spending years to develop new drugs and vaccines, oligo therapies are quickly providing ...
Design and application of circular RNAs with protein-sponge function
Schreiner S, Didio A, Hung LH, Bindereif A. Nucleic Acids Res. 2020 Nov 24:gkaa1085 Pubmed
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia.
Jiang L, Park JS, Yin L, Laureano R, Jacquinet E, Yang J, Liang S, Frassetto A, Zhuo J, Yan X, Zhu X, Fortucci S, Hoar K, Mihai C, Tunkey C, Presnyak V, Benenato KE, Lukacs CM, Martini PGV, Guey LT. Nat Commun. 2020 Oct 21;11(1):5339. ...
Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study
Adams D, Polydefkis M, González-Duarte A, Wixner J, Kristen AV, Schmidt HH, Berk JL, Losada López IA, Dispenzieri A, Quan D, Conceição IM, Slama MS, Gillmore JD, Kyriakides T, Ajroud-Driss S, Waddington-Cruz M, Mezei MM, Planté-Bordeneuve V, Attarian S, Mauricio E, Brannagan TH 3rd, Ueda ...
Intracellular delivery of therapeutic antisense oligonucleotides targeting mRNA coding mitochondrial proteins by cell-penetrating peptides
Cerrato CP, Kivijärvi T, Tozzi R, Lehto T, Gestin M, Langel Ü. J Mater Chem B. 2020 Epub 2020 Nov 11. Pubmed
Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding Affinity between Aptamer and Low Molecular Weight Compounds
Bottari F, Daems E, de Vries AM, Van Wielendaele P, Trashin S, Blust R, Sobott F, Madder A, Martins JC, De Wael K. J Am Chem Soc. 2020 Nov 18;142(46):19622-19630. Pubmed
Assessment of Aptamer-Targeted Contrast Agents for Monitoring of Blood Clots in Computed Tomography and Fluoroscopy Imaging
Koudrina A, O'Brien J, Garcia R, Boisjoli S, Kan PTM, Tsai EC, DeRosa MC. Bioconjug Chem. 2020 Nov 24. Pubmed
Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis
Leclair NK, Brugiolo M, Urbanski L, Lawson SC, Thakar K, Yurieva M, George J, Hinson JT, Cheng A, Graveley BR, Anczuków O. Mol Cell. 2020 Nov 19;80(4):648-665.e9. Pubmed
Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo
Asami Y, Nagata T, Yoshioka K, Kunieda T, Yoshida-Tanaka K, Bennett CF, Seth PP, Yokota T. Mol Ther. 2020 Nov 25:S1525-0016(20)30551-7. Pubmed
Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis
Shen M, Xie S, Rowicki M, Michel S, Wei Y, Hang X, Wan L, Lu X, Yuan M, Jin JF, Jaschinski F, Zhou T, Klar R, Kang Y. Cancer Res. 2020 Nov 25:canres.1876.2020. Pubmed
