Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis
Leclair NK, Brugiolo M, Urbanski L, Lawson SC, Thakar K, Yurieva M, George J, Hinson JT, Cheng A, Graveley BR, Anczuków O. Mol Cell. 2020 Nov 19;80(4):648-665.e9. Pubmed
Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo
Asami Y, Nagata T, Yoshioka K, Kunieda T, Yoshida-Tanaka K, Bennett CF, Seth PP, Yokota T. Mol Ther. 2020 Nov 25:S1525-0016(20)30551-7. Pubmed
Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis
Shen M, Xie S, Rowicki M, Michel S, Wei Y, Hang X, Wan L, Lu X, Yuan M, Jin JF, Jaschinski F, Zhou T, Klar R, Kang Y. Cancer Res. 2020 Nov 25:canres.1876.2020. Pubmed
Interview with Eric P. Van Der Veer, PhD
Eric P. Van Der Veer, PhD Chief Scientific Officer Hybridize Therapeutics How did you become interested in the field of oligonucleotides? After years of highly fundamental research geared towards understanding how splice modulation mediated by RNA-binding proteins impacts cellular differentiation, I was challenged ...
The N-Lorem Foundation
Presenter: Stanley T. Crooke, MD, PhD Ionis Pharmaceuticals Date: February 9th, 2021 Description: The purpose of this presentation is to formally introduce n-Lorem to OTS and to summarize progress since being founded in January 2020. Recording of the webinar: Click play to view ...
Modified aptamers as reagents to characterize recombinant human erythropoietin products
Jankowski W, Lagassé HAD, Chang WC, McGill J, Jankowska KI, Gelinas AD, Janjic N, Sauna ZE. Sci Rep. 2020 Oct 29;10(1):18593. Pubmed
Determination of isoform-specific RNA structure with nanopore long reads
Aw JGA, Lim SW, Wang JX, Lambert FRP, Tan WT, Shen Y, Zhang Y, Kaewsapsak P, Li C, Ng SB, Vardy LA, Tan MH, Nagarajan N, Wan Y. Nat Biotechnol. 2020 Oct 26 Pubmed
COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
Sahin U, Muik A, Derhovanessian E, Vogler I, Kranz LM, Vormehr M, Baum A, Pascal K, Quandt J, Maurus D, Brachtendorf S, Lörks V, Sikorski J, Hilker R, Becker D, Eller AK, Grützner J, Boesler C, Rosenbaum C, Kühnle MC, Luxemburger U, Kemmer-Brück A, Langer ...
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
Walsh EE, Frenck RW Jr, Falsey AR, Kitchin N, Absalon J, Gurtman A, Lockhart S, Neuzil K, Mulligan MJ, Bailey R, Swanson KA, Li P, Koury K, Kalina W, Cooper D, Fontes-Garfias C, Shi PY, Türeci Ö, Tompkins KR, Lyke KE, Raabe V, Dormitzer PR, ...
Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
Badri P, Jiang X, Borodovsky A, Najafian N, Kim J, Clausen VA, Goel V, Habtemariam B, Robbie GJ. Clin Pharmacokinet. 2020 Oct 13.
