RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
Urak KT, Blanco GN, Shubham S, Lin LH, Dassie JP, Thiel WH, Chen Y, Sonkar VK, Lei B, Murthy S, Gutierrez WR, Wilson ME, Stiber JA, Klesney-Tait J, Dayal S, Miller FJ Jr, Giangrande PH. Nat Commun. 2019 Jan 10;10(1):116. The three joint first authors: ...
An Overview of Chemical Modifications to CRISPR RNA
Presenter: Keith Gagnon, Southern Illinois University, USA Date: March 21, 2019 Description: CRISPR-based genome editing has emerged as an exciting technology for biomedical and therapeutic applications. Since 2015, a number of studies have explored the effects of chemically modifying the guide RNA components of ...
ApoE attenuates unresolvable inflammation by complex formation with activated C1q
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky ...
Long Non-coding RNA ECRAR Triggers Post-natal Myocardial Regeneration by Activating ERK1/2 Signaling
Chen Y, Li X, Li B, Wang H, Li M, Huang S, Sun Y, Chen G, Si X, Huang C, Liao W, Liao Y, Bin J. Mol Ther. 2019 Jan 2;27(1):29-45. PubMed
Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing
Butin-Israeli V, Bui TM, Wiesolek HL, Mascarenhas L, Lee JJ, Mehl LC, Knutson KR, Adam SA, Goldman RD, Beyder A, Wiesmuller L, Hanauer SB, Sumagin R. J Clin Invest. 2019 Jan 14. pii: 122085. PubMed
Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates
Lim KRQ, Echigoya Y, Nagata T, Kuraoka M, Kobayashi M, Aoki Y, Partridge T, Maruyama R, Takeda S, Yokota T. Mol Ther. 2019 Jan 2;27(1):76-86. PubMed
Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
Merkle T, Merz S, Reautschnig P, Blaha A, Li Q, Vogel P, Wettengel J, Li JB, Stafforst T. Nat Biotechnol. 2019 Jan 28. PubMed
RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
Urak KT, Blanco GN, Shubham S, Lin LH, Dassie JP, Thiel WH, Chen Y, Sonkar VK, Lei B, Murthy S, Gutierrez WR, Wilson ME, Stiber JA, Klesney-Tait J, Dayal S, Miller FJ Jr, Giangrande PH. Nat Commun. 2019 Jan 10;10(1):116. PubMed
Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated ‘don’t-eat-me’ signal
Liu M, O'Connor RS, Trefely S, Graham K, Snyder NW, Beatty GL. Nat Immunol. 2019 Jan 21. PubMed
Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis
Solomon SD, Adams D, Kristen A, Grogan M, González-Duarte A, Maurer MS, Merlini G, Damy T, Slama MS, Brannagan TH 3rd, Dispenzieri A, Berk JL, Shah AM, Garg P, Vaishnaw A, Karsten V, Chen J, Gollob J, Vest J, Suhr O. Circulation. 2019 Jan 22;139(4):431-443. ...
